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Monosomal complex karyotype in pediatric mixed phenotype acute leukemia. 2011

Elisa Tassano, and Elisa Tavella, and Concetta Micalizzi, and Francesca Scuderi, and Cristina Cuoco, and Cristina Morerio
Laboratorio di Citogenetica Ematoncologica, Istituto Di Ricovero e Cura a Carattere Scientifico Istituto Giannina Gaslini, Genova, Italy.

We report on a pediatric case of mixed phenotype acute leukemia with myeloid and T-lymphoid differentiation, a single myeloblastic cell population, and a monosomal complex karyotype. The patient, a 5-year-old girl, responded to acute myeloid leukemia-oriented therapy that was decided based on the morphological appearance of blast cells. In this study, we analyzed the patient's peculiar chromosomal abnormalities, as evaluated by array comparative genomic hybridization in combination with multicolor fluorescence in situ hybridization and cytogenetic analyses.

UI MeSH Term Description Entries
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D015456 Leukemia, Biphenotypic, Acute An acute leukemia exhibiting cell features characteristic of both the myeloid and lymphoid lineages and probably arising from MULTIPOTENT STEM CELLS. B- and T-Cell Acute Lymphoblastic Leukemia,B- and T-Cell Leukemia, Acute,Leukemia, Lymphocytic, Acute, Mixed-Cell,Leukemia, Mixed, B- and T-Cell,Leukemia, Mixed-Cell,Lymphocytic Leukemia, Acute, B- and T-Cell,Acute Biphenotypic Leukemia,B and T Cell Acute Lymphoblastic Leukemia,B and T Cell Leukemia, Acute,Biphenotypic Acute Leukemia,Hybrid Acute Leukemias,Leukemia, Lymphocytic, Acute, Mixed Cell,Leukemia, Mixed, B and T Cell,Lymphocytic Leukemia, Acute, B and T Cell,Mixed-Lineage Acute Leukemias,Acute Biphenotypic Leukemias,Acute Leukemia, Biphenotypic,Acute Leukemia, Hybrid,Acute Leukemia, Mixed-Lineage,Acute Leukemias, Biphenotypic,Acute Leukemias, Hybrid,Acute Leukemias, Mixed-Lineage,Biphenotypic Acute Leukemias,Biphenotypic Leukemia, Acute,Biphenotypic Leukemias, Acute,Hybrid Acute Leukemia,Leukemia, Acute Biphenotypic,Leukemia, Biphenotypic Acute,Leukemia, Hybrid Acute,Leukemia, Mixed Cell,Leukemia, Mixed-Lineage Acute,Leukemias, Acute Biphenotypic,Leukemias, Biphenotypic Acute,Leukemias, Hybrid Acute,Leukemias, Mixed-Cell,Leukemias, Mixed-Lineage Acute,Mixed Lineage Acute Leukemias,Mixed-Cell Leukemia,Mixed-Cell Leukemias,Mixed-Lineage Acute Leukemia
D017404 In Situ Hybridization, Fluorescence A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei. FISH Technique,Fluorescent in Situ Hybridization,Hybridization in Situ, Fluorescence,FISH Technic,Hybridization in Situ, Fluorescent,In Situ Hybridization, Fluorescent,FISH Technics,FISH Techniques,Technic, FISH,Technics, FISH,Technique, FISH,Techniques, FISH
D055028 Comparative Genomic Hybridization A method for comparing two sets of chromosomal DNA by analyzing differences in the copy number and location of specific sequences. It is used to look for large sequence changes such as deletions, duplications, amplifications, or translocations. Array Comparative Genomic Hybridization,Array-Based Comparative Genomic Hybridization,Comparative Genome Hybridization,Array Based Comparative Genomic Hybridization,Comparative Genome Hybridizations,Comparative Genomic Hybridizations,Genome Hybridization, Comparative,Genome Hybridizations, Comparative,Genomic Hybridization, Comparative,Genomic Hybridizations, Comparative,Hybridization, Comparative Genome,Hybridization, Comparative Genomic,Hybridizations, Comparative Genome,Hybridizations, Comparative Genomic
D059785 Karyotype The full set of CHROMOSOMES presented as a systematized array of METAPHASE chromosomes from a photomicrograph of a single CELL NUCLEUS arranged in pairs in descending order of size and according to the position of the CENTROMERE. (From Stedman, 25th ed) Karyotypes
D020732 Cytogenetic Analysis Examination of CHROMOSOMES to diagnose, classify, screen for, or manage genetic diseases and abnormalities. Following preparation of the sample, KARYOTYPING is performed and/or the specific chromosomes are analyzed. Cytogenetic Techniques,Molecular Cytogenetic Techniques,Cytogenetic Technics,Molecular Cytogenetic Technics,Analyses, Cytogenetic,Analysis, Cytogenetic,Cytogenetic Analyses,Cytogenetic Technic,Cytogenetic Technic, Molecular,Cytogenetic Technics, Molecular,Cytogenetic Technique,Cytogenetic Technique, Molecular,Cytogenetic Techniques, Molecular,Molecular Cytogenetic Technic,Molecular Cytogenetic Technique,Technic, Cytogenetic,Technic, Molecular Cytogenetic,Technics, Cytogenetic,Technics, Molecular Cytogenetic,Technique, Cytogenetic,Technique, Molecular Cytogenetic,Techniques, Cytogenetic,Techniques, Molecular Cytogenetic

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