BIOMAT Database Logo BIOMAT Database Logo

Direct comparison of fluorodeoxyglucose positron emission tomography and arterial spin labeling magnetic resonance imaging in Alzheimer's disease. 2012

Erik S Musiek, and Yufen Chen, and Marc Korczykowski, and Babak Saboury, and Patricia M Martinez, and Janet S Reddin, and Abass Alavi, and Daniel Y Kimberg, and David A Wolk, and Per Julin, and Andrew B Newberg, and Steven E Arnold, and John A Detre
Department of Neurology, University of Pennsylvania, Philadelphia, USA.

BACKGROUND The utility of fluorodeoxyglucose positron emission tomography (FDG-PET) imaging in Alzheimer's disease (AD) diagnosis has been well established. Recently, measurement of cerebral blood flow using arterial spin labeling magnetic resonance imaging (ASL-MRI) has shown diagnostic potential in AD, although it has never been directly compared with FDG-PET. METHODS We used a novel imaging protocol to obtain FDG-PET and ASL-MRI images concurrently in 17 AD patients and 19 age-matched control subjects. Paired FDG-PET and ASL-MRI images from 19 control subjects and 15 AD patients were included for qualitative analysis, and paired images from 18 control subjects and 13 AD patients were suitable for quantitative analyses. RESULTS The combined imaging protocol was well tolerated. Both modalities revealed similar regional abnormalities in AD, as well as comparable sensitivity and specificity for the detection of AD after visual review by two expert readers. Interobserver agreement was better for FDG-PET (κ: 0.75, standard error: 0.12) than ASL-MRI (κ: 0.51, standard error: 0.15); intermodality agreement was moderate to strong (κ: 0.45-0.61); and readers were more confident of FDG-PET reads. Simple quantitative analysis of global cerebral fluorodeoxyglucose uptake (FDG-PET) or whole-brain cerebral blood flow (ASL-MRI) showed excellent diagnostic accuracy for both modalities, with area under receiver operating characteristic curves of 0.90 for FDG-PET (95% confidence interval: 0.79-0.99) and 0.91 for ASL-MRI (95% confidence interval: 0.80-1.00). CONCLUSIONS Our results demonstrate that FDG-PET and ASL-MRI identify similar regional abnormalities and have comparable diagnostic accuracy in a small population of AD patients, and support the further study of ASL-MRI in dementia diagnosis.

UI MeSH Term Description Entries
D008279 Magnetic Resonance Imaging Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques. Chemical Shift Imaging,MR Tomography,MRI Scans,MRI, Functional,Magnetic Resonance Image,Magnetic Resonance Imaging, Functional,Magnetization Transfer Contrast Imaging,NMR Imaging,NMR Tomography,Tomography, NMR,Tomography, Proton Spin,fMRI,Functional Magnetic Resonance Imaging,Imaging, Chemical Shift,Proton Spin Tomography,Spin Echo Imaging,Steady-State Free Precession MRI,Tomography, MR,Zeugmatography,Chemical Shift Imagings,Echo Imaging, Spin,Echo Imagings, Spin,Functional MRI,Functional MRIs,Image, Magnetic Resonance,Imaging, Magnetic Resonance,Imaging, NMR,Imaging, Spin Echo,Imagings, Chemical Shift,Imagings, Spin Echo,MRI Scan,MRIs, Functional,Magnetic Resonance Images,Resonance Image, Magnetic,Scan, MRI,Scans, MRI,Shift Imaging, Chemical,Shift Imagings, Chemical,Spin Echo Imagings,Steady State Free Precession MRI
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D001931 Brain Mapping Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures. Brain Electrical Activity Mapping,Functional Cerebral Localization,Topographic Brain Mapping,Brain Mapping, Topographic,Functional Cerebral Localizations,Mapping, Brain,Mapping, Topographic Brain
D002560 Cerebrovascular Circulation The circulation of blood through the BLOOD VESSELS of the BRAIN. Brain Blood Flow,Regional Cerebral Blood Flow,Cerebral Blood Flow,Cerebral Circulation,Cerebral Perfusion Pressure,Circulation, Cerebrovascular,Blood Flow, Brain,Blood Flow, Cerebral,Brain Blood Flows,Cerebral Blood Flows,Cerebral Circulations,Cerebral Perfusion Pressures,Circulation, Cerebral,Flow, Brain Blood,Flow, Cerebral Blood,Perfusion Pressure, Cerebral,Pressure, Cerebral Perfusion
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D000369 Aged, 80 and over Persons 80 years of age and older. Oldest Old
D000544 Alzheimer Disease A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57) Acute Confusional Senile Dementia,Alzheimer's Diseases,Dementia, Alzheimer Type,Dementia, Senile,Presenile Alzheimer Dementia,Senile Dementia, Alzheimer Type,Alzheimer Dementia,Alzheimer Disease, Early Onset,Alzheimer Disease, Late Onset,Alzheimer Sclerosis,Alzheimer Syndrome,Alzheimer Type Senile Dementia,Alzheimer's Disease,Alzheimer's Disease, Focal Onset,Alzheimer-Type Dementia (ATD),Dementia, Presenile,Dementia, Primary Senile Degenerative,Early Onset Alzheimer Disease,Familial Alzheimer Disease (FAD),Focal Onset Alzheimer's Disease,Late Onset Alzheimer Disease,Primary Senile Degenerative Dementia,Senile Dementia, Acute Confusional,Alzheimer Dementias,Alzheimer Disease, Familial (FAD),Alzheimer Diseases,Alzheimer Type Dementia,Alzheimer Type Dementia (ATD),Alzheimers Diseases,Dementia, Alzheimer,Dementia, Alzheimer-Type (ATD),Familial Alzheimer Diseases (FAD),Presenile Dementia,Sclerosis, Alzheimer,Senile Dementia

Related Publications

Erik S Musiek, and Yufen Chen, and Marc Korczykowski, and Babak Saboury, and Patricia M Martinez, and Janet S Reddin, and Abass Alavi, and Daniel Y Kimberg, and David A Wolk, and Per Julin, and Andrew B Newberg, and Steven E Arnold, and John A Detre
Discriminative Power of Arterial Spin Labeling Magnetic Resonance Imaging and 18F-Fluorodeoxyglucose Positron Emission Tomography Changes for Amyloid-β-Positive Subjects in the Alzheimer's Disease Continuum.
January 2016, Neuro-degenerative diseases,
Erik S Musiek, and Yufen Chen, and Marc Korczykowski, and Babak Saboury, and Patricia M Martinez, and Janet S Reddin, and Abass Alavi, and Daniel Y Kimberg, and David A Wolk, and Per Julin, and Andrew B Newberg, and Steven E Arnold, and John A Detre
Positron emission tomography/magnetic resonance hybrid scanner imaging of cerebral blood flow using (15)O-water positron emission tomography and arterial spin labeling magnetic resonance imaging in newborn piglets.
November 2015, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism,
Erik S Musiek, and Yufen Chen, and Marc Korczykowski, and Babak Saboury, and Patricia M Martinez, and Janet S Reddin, and Abass Alavi, and Daniel Y Kimberg, and David A Wolk, and Per Julin, and Andrew B Newberg, and Steven E Arnold, and John A Detre
Comparison of cerebral blood flow acquired by simultaneous [15O]water positron emission tomography and arterial spin labeling magnetic resonance imaging.
August 2014, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism,
Erik S Musiek, and Yufen Chen, and Marc Korczykowski, and Babak Saboury, and Patricia M Martinez, and Janet S Reddin, and Abass Alavi, and Daniel Y Kimberg, and David A Wolk, and Per Julin, and Andrew B Newberg, and Steven E Arnold, and John A Detre
18F-Fluorodeoxyglucose Positron Emission Tomography/Magnetic Resonance in Lymphoma: Comparison With 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography and With the Addition of Magnetic Resonance Diffusion-Weighted Imaging.
March 2016, Investigative radiology,
Erik S Musiek, and Yufen Chen, and Marc Korczykowski, and Babak Saboury, and Patricia M Martinez, and Janet S Reddin, and Abass Alavi, and Daniel Y Kimberg, and David A Wolk, and Per Julin, and Andrew B Newberg, and Steven E Arnold, and John A Detre
18F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography/Magnetic Resonance Imaging in Neurosarcoidosis.
January 2019, Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India,
Erik S Musiek, and Yufen Chen, and Marc Korczykowski, and Babak Saboury, and Patricia M Martinez, and Janet S Reddin, and Abass Alavi, and Daniel Y Kimberg, and David A Wolk, and Per Julin, and Andrew B Newberg, and Steven E Arnold, and John A Detre
Identifying Hypoperfusion in Moyamoya Disease With Arterial Spin Labeling and an [15O]-Water Positron Emission Tomography/Magnetic Resonance Imaging Normative Database.
February 2019, Stroke,
Erik S Musiek, and Yufen Chen, and Marc Korczykowski, and Babak Saboury, and Patricia M Martinez, and Janet S Reddin, and Abass Alavi, and Daniel Y Kimberg, and David A Wolk, and Per Julin, and Andrew B Newberg, and Steven E Arnold, and John A Detre
18F-Fluorodeoxyglucose Positron Emission Tomography/Magnetic Resonance Imaging Appearance of Gastrointestinal Behcet's Disease.
February 2022, Molecular imaging and radionuclide therapy,
Erik S Musiek, and Yufen Chen, and Marc Korczykowski, and Babak Saboury, and Patricia M Martinez, and Janet S Reddin, and Abass Alavi, and Daniel Y Kimberg, and David A Wolk, and Per Julin, and Andrew B Newberg, and Steven E Arnold, and John A Detre
Comparison of cerebral blood flow measurement with [15O]-water positron emission tomography and arterial spin labeling magnetic resonance imaging: A systematic review.
May 2016, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism,
Erik S Musiek, and Yufen Chen, and Marc Korczykowski, and Babak Saboury, and Patricia M Martinez, and Janet S Reddin, and Abass Alavi, and Daniel Y Kimberg, and David A Wolk, and Per Julin, and Andrew B Newberg, and Steven E Arnold, and John A Detre
Fluorodeoxyglucose positron emission tomography/magnetic resonance imaging: current status, future aspects.
April 2014, PET clinics,
Erik S Musiek, and Yufen Chen, and Marc Korczykowski, and Babak Saboury, and Patricia M Martinez, and Janet S Reddin, and Abass Alavi, and Daniel Y Kimberg, and David A Wolk, and Per Julin, and Andrew B Newberg, and Steven E Arnold, and John A Detre
18F-fluorodeoxyglucose positron emission tomography and magnetic resonance imaging evaluation of chorea.
September 2018, Neurology international,
Copied contents to your clipboard!