BIOMAT Database Logo BIOMAT Database Logo

Osteoclast-rich undifferentiated carcinoma of the urinary bladder: an immunohistochemical study. 2011

Hiroo Kawano, and Shinsuke Tanaka, and Aya Ishii, and Dan Cui, and Satoshi Eguchi, and Osamu Hashimoto, and Eiji Ikeda
Department of Pathology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan. khiroo@yamaguchi-u.ac.jp

Osteoclast-rich undifferentiated carcinoma of the urinary tract is a rare tumor which histologically mimicks giant cell tumor of bone. The histogenesis of this tumor has not been clarified yet although its urothelial origin is proposed on the basis of positive reactions of an epithelial marker on mononuclear undifferentiated tumor cells and the existence of foci of a urothelial carcinoma component in some cases. We experienced a case of urinary bladder tumor diagnosed as osteoclastic-rich undifferentiated carcinoma, and performed an immunohistochemical study on the expression of various markers, including stem cell markers to further characterize the tumor properties. Immunohistochemically, CD56, nestin, and Sox2 were expressed in diffusely proliferating mononuclear tumor cells of undifferentiated features, suggesting the stemness properties of these cells. These findings might provide the clue as to the clarification of the pathogenesis of this rare tumor.

UI MeSH Term Description Entries
D007150 Immunohistochemistry Histochemical localization of immunoreactive substances using labeled antibodies as reagents. Immunocytochemistry,Immunogold Techniques,Immunogold-Silver Techniques,Immunohistocytochemistry,Immunolabeling Techniques,Immunogold Technics,Immunogold-Silver Technics,Immunolabeling Technics,Immunogold Silver Technics,Immunogold Silver Techniques,Immunogold Technic,Immunogold Technique,Immunogold-Silver Technic,Immunogold-Silver Technique,Immunolabeling Technic,Immunolabeling Technique,Technic, Immunogold,Technic, Immunogold-Silver,Technic, Immunolabeling,Technics, Immunogold,Technics, Immunogold-Silver,Technics, Immunolabeling,Technique, Immunogold,Technique, Immunogold-Silver,Technique, Immunolabeling,Techniques, Immunogold,Techniques, Immunogold-Silver,Techniques, Immunolabeling
D008297 Male Males
D008940 Mitotic Index An expression of the number of mitoses found in a stated number of cells. Index, Mitotic,Indices, Mitotic,Mitotic Indices
D010010 Osteoclasts A large multinuclear cell associated with the BONE RESORPTION. An odontoclast, also called cementoclast, is cytomorphologically the same as an osteoclast and is involved in CEMENTUM resorption. Odontoclasts,Cementoclast,Cementoclasts,Odontoclast,Osteoclast
D001743 Urinary Bladder A musculomembranous sac along the URINARY TRACT. URINE flows from the KIDNEYS into the bladder via the ureters (URETER), and is held there until URINATION. Bladder,Bladder Detrusor Muscle,Detrusor Urinae,Bladder Detrusor Muscles,Bladder, Urinary,Detrusor Muscle, Bladder,Detrusor Muscles, Bladder
D001749 Urinary Bladder Neoplasms Tumors or cancer of the URINARY BLADDER. Bladder Cancer,Bladder Neoplasms,Cancer of Bladder,Bladder Tumors,Cancer of the Bladder,Malignant Tumor of Urinary Bladder,Neoplasms, Bladder,Urinary Bladder Cancer,Bladder Cancers,Bladder Neoplasm,Bladder Tumor,Cancer, Bladder,Cancer, Urinary Bladder,Neoplasm, Bladder,Neoplasm, Urinary Bladder,Tumor, Bladder,Tumors, Bladder,Urinary Bladder Neoplasm
D002277 Carcinoma A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for "cancer." Carcinoma, Anaplastic,Carcinoma, Spindle-Cell,Carcinoma, Undifferentiated,Carcinomatosis,Epithelial Neoplasms, Malignant,Epithelioma,Epithelial Tumors, Malignant,Malignant Epithelial Neoplasms,Neoplasms, Malignant Epithelial,Anaplastic Carcinoma,Anaplastic Carcinomas,Carcinoma, Spindle Cell,Carcinomas,Carcinomatoses,Epithelial Neoplasm, Malignant,Epithelial Tumor, Malignant,Epitheliomas,Malignant Epithelial Neoplasm,Malignant Epithelial Tumor,Malignant Epithelial Tumors,Neoplasm, Malignant Epithelial,Spindle-Cell Carcinoma,Spindle-Cell Carcinomas,Tumor, Malignant Epithelial,Undifferentiated Carcinoma,Undifferentiated Carcinomas
D003937 Diagnosis, Differential Determination of which one of two or more diseases or conditions a patient is suffering from by systematically comparing and contrasting results of diagnostic measures. Diagnoses, Differential,Differential Diagnoses,Differential Diagnosis
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly

Related Publications

Hiroo Kawano, and Shinsuke Tanaka, and Aya Ishii, and Dan Cui, and Satoshi Eguchi, and Osamu Hashimoto, and Eiji Ikeda
An expanded immunohistochemical profile of osteoclast-rich undifferentiated carcinoma of the urinary tract.
June 2018, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc,
Hiroo Kawano, and Shinsuke Tanaka, and Aya Ishii, and Dan Cui, and Satoshi Eguchi, and Osamu Hashimoto, and Eiji Ikeda
Osteoclast-rich undifferentiated carcinoma of the urinary bladder: is it really an entity?
July 2010, Advances in anatomic pathology,
Hiroo Kawano, and Shinsuke Tanaka, and Aya Ishii, and Dan Cui, and Satoshi Eguchi, and Osamu Hashimoto, and Eiji Ikeda
[Undifferentiated small cell carcinoma of the urinary bladder. Clinicopathologic and immunohistochemical study].
January 1993, Archivos espanoles de urologia,
Hiroo Kawano, and Shinsuke Tanaka, and Aya Ishii, and Dan Cui, and Satoshi Eguchi, and Osamu Hashimoto, and Eiji Ikeda
Osteoclast-rich undifferentiated carcinomas of the urinary tract.
February 2006, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc,
Hiroo Kawano, and Shinsuke Tanaka, and Aya Ishii, and Dan Cui, and Satoshi Eguchi, and Osamu Hashimoto, and Eiji Ikeda
Osteoclast-rich undifferentiated carcinoma of the urinary tract: cytologic findings and literature review.
May 2010, Diagnostic cytopathology,
Hiroo Kawano, and Shinsuke Tanaka, and Aya Ishii, and Dan Cui, and Satoshi Eguchi, and Osamu Hashimoto, and Eiji Ikeda
Osteoclast-rich undifferentiated carcinoma of the bladder and the diagnostic usefulness of immunohistochemistry. A case report.
January 2023, Revista espanola de patologia : publicacion oficial de la Sociedad Espanola de Anatomia Patologica y de la Sociedad Espanola de Citologia,
Hiroo Kawano, and Shinsuke Tanaka, and Aya Ishii, and Dan Cui, and Satoshi Eguchi, and Osamu Hashimoto, and Eiji Ikeda
The osteoclast-type giant cell rich carcinoma of urinary bladder: A case series.
November 2022, Pathology, research and practice,
Hiroo Kawano, and Shinsuke Tanaka, and Aya Ishii, and Dan Cui, and Satoshi Eguchi, and Osamu Hashimoto, and Eiji Ikeda
Undifferentiated carcinoma: an immunohistochemical and ultrastructural study.
January 1993, Anticancer research,
Hiroo Kawano, and Shinsuke Tanaka, and Aya Ishii, and Dan Cui, and Satoshi Eguchi, and Osamu Hashimoto, and Eiji Ikeda
Sarcomatoid carcinoma of urinary bladder: immunohistochemical study of an uncommon case.
January 2002, Urologia internationalis,
Hiroo Kawano, and Shinsuke Tanaka, and Aya Ishii, and Dan Cui, and Satoshi Eguchi, and Osamu Hashimoto, and Eiji Ikeda
Urinary bladder paragangliomas. An immunohistochemical study.
January 1988, Archives of pathology & laboratory medicine,
Copied contents to your clipboard!