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Twenty-one patients with postherpetic neuralgia of two- to 84-months duration participated in a double-blind, placebo-controlled study of oral acyclovir. Pain perception was assessed with the Melzack Pain Questionnaire at baseline and at two-to six-week intervals during the ensuing six months. Clinically significant pain reduction occurred in eight patients: four received acyclovir, and four received a placebo. Several treatment strategies have been advocated for relief of postherpetic neuralgia. Results of the present study demonstrate the need for a double-blind, placebo-controlled paradigm to substantiate the efficacy of new clinical approaches. The same caveat applies to the more common syndromes encountered in psychiatric practice.
O S Surman, and
T Flynn, and
R T Schooley, and
L Baer, and
S Parker, and
M S Hirsch, and
L G Davis
November 2001,
Pain,
O S Surman, and
T Flynn, and
R T Schooley, and
L Baer, and
S Parker, and
M S Hirsch, and
L G Davis
April 2002,
Pain,
O S Surman, and
T Flynn, and
R T Schooley, and
L Baer, and
S Parker, and
M S Hirsch, and
L G Davis
April 2002,
Pain,
O S Surman, and
T Flynn, and
R T Schooley, and
L Baer, and
S Parker, and
M S Hirsch, and
L G Davis
July 1987,
Journal of the American Dental Association (1939),
O S Surman, and
T Flynn, and
R T Schooley, and
L Baer, and
S Parker, and
M S Hirsch, and
L G Davis
January 1985,
Acta dermato-venereologica,
O S Surman, and
T Flynn, and
R T Schooley, and
L Baer, and
S Parker, and
M S Hirsch, and
L G Davis
October 2013,
The Clinical journal of pain,
O S Surman, and
T Flynn, and
R T Schooley, and
L Baer, and
S Parker, and
M S Hirsch, and
L G Davis
May 2019,
Pain,
O S Surman, and
T Flynn, and
R T Schooley, and
L Baer, and
S Parker, and
M S Hirsch, and
L G Davis
October 1991,
The Journal of infectious diseases,
O S Surman, and
T Flynn, and
R T Schooley, and
L Baer, and
S Parker, and
M S Hirsch, and
L G Davis
March 1993,
The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses,
O S Surman, and
T Flynn, and
R T Schooley, and
L Baer, and
S Parker, and
M S Hirsch, and
L G Davis
August 2019,
Pain,
