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Islet amyloid polypeptide (IAPP) is a recently discovered pancreatic islet hormone which is stored with insulin in the secretory vesicles of beta cells. Several lines of evidence suggested that IAPP might affect glucose-stimulated insulin secretion and, therefore, might play a role in the development of impaired insulin secretion which is typical of type 2 diabetes. In this study, the effects of human IAPP (amide) on glucose-stimulated insulin secretion was evaluated in the isolated perfused rat pancreas. IAPP in concentrations from 5 x 10(-12) to 10(-7) M had no significant effects on insulin secretion. IAPP, therefore, does not appear to be a significant modulator of glucose-stimulated insulin secretion at concentrations that are physiologically relevant.
T D O'Brien, and
P Westermark, and
K H Johnson
April 1989,
Biochemical and biophysical research communications,
T D O'Brien, and
P Westermark, and
K H Johnson
January 1992,
Diabetes research and clinical practice,
T D O'Brien, and
P Westermark, and
K H Johnson
September 1996,
Acta physiologica Scandinavica,
T D O'Brien, and
P Westermark, and
K H Johnson
March 1990,
Biochemical and biophysical research communications,
T D O'Brien, and
P Westermark, and
K H Johnson
August 2005,
Nihon rinsho. Japanese journal of clinical medicine,
T D O'Brien, and
P Westermark, and
K H Johnson
April 1999,
The Journal of nutritional biochemistry,
T D O'Brien, and
P Westermark, and
K H Johnson
July 1981,
Endocrinology,
T D O'Brien, and
P Westermark, and
K H Johnson
May 1996,
Regulatory peptides,
T D O'Brien, and
P Westermark, and
K H Johnson
November 1999,
Pancreas,
T D O'Brien, and
P Westermark, and
K H Johnson
January 1997,
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract,
