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Bacterial production of the tunicate-derived antitumor cyclic depsipeptide didemnin B. 2011
Moriya Tsukimoto, and
Masato Nagaoka, and
Yoshiyuki Shishido, and
Junji Fujimoto, and
Fukiko Nishisaka, and
Sachiko Matsumoto, and
Enjuro Harunari, and
Chiaki Imada, and
Takeshi Matsuzaki
Yakult Central Institute for Microbiological Research, 1796 Yaho, Kunitachi-shi, Tokyo 186-8650, Japan. moriyatsukimotto@yakult.comjp
Natural products obtained from marine invertebrates such as sponges and tunicates are attractive sources of drugs. However, a critical obstacle in the development of these compounds is the problem of supply. In most cases, neither chemical synthesis nor mariculture of invertebrates is economically feasible. Due to structural similarities, many marine natural products are suspected to be produced by associated microorganisms. A favorable strategy for the production of such compounds is to use culturable microorganisms. Here we report that didemnin B, a tunicate-derived depsipeptide, has been isolated from a culturable bacterium, Tistrella mobilis YIT 12409.
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