Fragrance material review on phenylethyl alcohol. 2012

J Scognamiglio, and L Jones, and C S Letizia, and A M Api
Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA. jscognamiglio@rifm.org

A toxicologic and dermatologic review of phenylethyl alcohol when used as a fragrance ingredient is presented. Phenylethyl alcohol is a member of the fragrance structural group Aryl Alkyl Alcohols and is a primary alcohol. The AAAs are a structurally diverse class of fragrance ingredients that includes primary, secondary, and tertiary alkyl alcohols covalently bonded to an aryl (Ar) group, which may be either a substituted or unsubstituted benzene ring. The common structural element for the AAA fragrance ingredients is an alcohol group -C-(R1)(R2)OH and generically the AAA fragrances can be represented as an Ar-C-(R1)(R2)OH or Ar-Alkyl-C-(R1)(R2)OH group. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for phenylethyl alcohol were evaluated then summarized and includes physical properties, acute toxicity, skin irritation, mucous membrane (eye) irritation, skin sensitization, toxicokinetics, repeated dose, reproductive toxicity, genotoxicity, and carcinogenicity data. A safety assessment of the entire Aryl Alkyl Alcohols will be published simultaneously with this document; please refer to Belsito et al. (2012) for an overall assessment of the safe use of this material and all Aryl Alkyl Alcohols in fragrances.

UI MeSH Term Description Entries
D008297 Male Males
D010476 Perfume A substance, extract, or preparation for diffusing or imparting an agreeable or attractive smell, especially a fluid containing fragrant natural oils extracted from flowers, woods, etc., or similar synthetic oils. (Random House Unabridged Dictionary, 2d ed)
D010626 Phenylethyl Alcohol An antimicrobial, antiseptic, and disinfectant that is used also as an aromatic essence and preservative in pharmaceutics and perfumery. Benzyl Carbinol,Phenethyl Alcohol,Phenylethanol,2-Phenylethanol,beta-Phenylethanol,2 Phenylethanol,Alcohol, Phenethyl,Alcohol, Phenylethyl,Carbinol, Benzyl,beta Phenylethanol
D005260 Female Females
D006168 Guinea Pigs A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research. Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012867 Skin The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
D017207 Rats, Sprague-Dawley A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company. Holtzman Rat,Rats, Holtzman,Sprague-Dawley Rat,Rats, Sprague Dawley,Holtzman Rats,Rat, Holtzman,Rat, Sprague-Dawley,Sprague Dawley Rat,Sprague Dawley Rats,Sprague-Dawley Rats
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus

Related Publications

J Scognamiglio, and L Jones, and C S Letizia, and A M Api
September 2012, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
J Scognamiglio, and L Jones, and C S Letizia, and A M Api
September 2012, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
J Scognamiglio, and L Jones, and C S Letizia, and A M Api
September 2012, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
J Scognamiglio, and L Jones, and C S Letizia, and A M Api
September 2012, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
J Scognamiglio, and L Jones, and C S Letizia, and A M Api
September 2012, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
J Scognamiglio, and L Jones, and C S Letizia, and A M Api
September 2012, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
J Scognamiglio, and L Jones, and C S Letizia, and A M Api
November 2008, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
J Scognamiglio, and L Jones, and C S Letizia, and A M Api
November 2008, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
J Scognamiglio, and L Jones, and C S Letizia, and A M Api
June 2005, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
J Scognamiglio, and L Jones, and C S Letizia, and A M Api
July 2010, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
Copied contents to your clipboard!