The purpose of this study was to compare the long-term and short-term periodontal response to three different modalities of fixed prosthodontic tooth replacement. Posterior proximal sites adjacent to abutment teeth supporting etched metal and two designs of conventional fixed partial dentures (FPDs) were assessed 6 months to 5 years after insertion. For the long-term observation, the etched metal resin-bonded FPDs had significantly greater plaque scores than both of the conventional designs. The resin-bonded FPD group had statistically, but not clinically, significant increased probing depths than the supragingival FPD group. In spite of the increased levels of supragingival plaque associated with the etched metal FPD, this type of fixed prosthesis was no more injurious to the periodontium than the subgingival conventional FPD designs.