BACKGROUND People with serious mental illness experience an erosion of functioning in day-to-day life over a protracted period of time. There is also evidence to suggest that people with serious mental illness have a greater risk of experiencing oral disease and have greater oral treatment needs than the general population. However, oral health has never been seen as a priority in people suffering with serious mental illness. Poor oral health has a serious impact on quality of life, everyday functioning, social inclusion and self-esteem. We feel that oral healthcare advice could have a positive impact on this disadvantaged population. OBJECTIVE To assess the effectiveness of oral health advice in reducing morbidity, mortality and preserving the quality of life in people with serious mental illness. METHODS We searched the Cochrane Schizophrenia Group Trials Register (October 2009) which is based on regular searches of CENTRAL, MEDLINE, EMBASE, CINAHL and PsycINFO. METHODS We planned to include all randomised clinical trials focusing on oral health advice versus standard care or comparing oral health advice with other more focused methods of delivering care or information. METHODS The review authors (GT, AC, WK) independently screened search results and did not identify any studies that fulfilled the review's criteria. RESULTS We did not identify any studies that met our inclusion criteria. CONCLUSIONS Healthcare professionals should be more proactive in liaising with oral health professionals in developing novel ways to cater for the needs of people with serious mental illness.