FoxO3a changes in pyramidal neurons and expresses in non-pyramidal neurons and astrocytes in the gerbil hippocampal CA1 region after transient cerebral ischemia. 2012

Ki-Yeon Yoo, and Seung-Hae Kwon, and Choong Hyun Lee, and Bingchun Yan, and Joon Ha Park, and Ji Hyeon Ahn, and Jung Hoon Choi, and Taek Geun Ohk, and Jun Hwi Cho, and Moo-Ho Won
Department of Oral Anatomy, College of Dentistry, Gangneung-Wonju National University, Gangneung, 210-702, South Korea.

The forkhead box O (FoxO) proteins regulate processes ranging from cell longevity to cell apoptosis and function as transcription factors. FoxO3a is expressed throughout the brain including the hippocampus. In the present study, we investigated the changes in FoxO3a immunoreactivity and its protein levels in the gerbil hippocampal CA1 region after 5 min of transient global cerebral ischemia. FoxO3a immunoreactivity and protein levels in the ischemic CA1 region, which is very vulnerable to ischemic damage, were slightly decreased from 3 h after ischemia-reperfusion (I-R) and maintained until 12 h after I-R. One and 2 days after I-R, FoxO3a immunoreactivity and protein levels were similar to those in the sham-operated group. At 3 days after I-R, FoxO3a immunoreactivity and protein levels were markedly increased in the CA1 region. FoxO3a immunoreactivity was hardly detected in pyramidal neurons from 5 days after I-R; however, at 5 days after I-R, FoxO3a immunoreactivity was detected in astrocytes and GABAergic interneurons of the ischemic CA1 region. These results indicate that both FoxO3a immunoreactivity and protein levels are distinctively altered in the ischemic CA1 region after transient cerebral ischemia, and that the changes in FoxO3a expression may be related to the ischemia-induced delayed neuronal death.

UI MeSH Term Description Entries
D007150 Immunohistochemistry Histochemical localization of immunoreactive substances using labeled antibodies as reagents. Immunocytochemistry,Immunogold Techniques,Immunogold-Silver Techniques,Immunohistocytochemistry,Immunolabeling Techniques,Immunogold Technics,Immunogold-Silver Technics,Immunolabeling Technics,Immunogold Silver Technics,Immunogold Silver Techniques,Immunogold Technic,Immunogold Technique,Immunogold-Silver Technic,Immunogold-Silver Technique,Immunolabeling Technic,Immunolabeling Technique,Technic, Immunogold,Technic, Immunogold-Silver,Technic, Immunolabeling,Technics, Immunogold,Technics, Immunogold-Silver,Technics, Immunolabeling,Technique, Immunogold,Technique, Immunogold-Silver,Technique, Immunolabeling,Techniques, Immunogold,Techniques, Immunogold-Silver,Techniques, Immunolabeling
D008297 Male Males
D009474 Neurons The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM. Nerve Cells,Cell, Nerve,Cells, Nerve,Nerve Cell,Neuron
D002545 Brain Ischemia Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION. Cerebral Ischemia,Ischemic Encephalopathy,Encephalopathy, Ischemic,Ischemia, Cerebral,Brain Ischemias,Cerebral Ischemias,Ischemia, Brain,Ischemias, Cerebral,Ischemic Encephalopathies
D005849 Gerbillinae A subfamily of the Muridae consisting of several genera including Gerbillus, Rhombomys, Tatera, Meriones, and Psammomys. Gerbils,Jird,Meriones,Psammomys,Rats, Sand,Gerbil,Jirds,Merione,Rat, Sand,Sand Rat,Sand Rats
D006624 Hippocampus A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation. Ammon Horn,Cornu Ammonis,Hippocampal Formation,Subiculum,Ammon's Horn,Hippocampus Proper,Ammons Horn,Formation, Hippocampal,Formations, Hippocampal,Hippocampal Formations,Hippocampus Propers,Horn, Ammon,Horn, Ammon's,Proper, Hippocampus,Propers, Hippocampus,Subiculums
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D015153 Blotting, Western Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes. Immunoblotting, Western,Western Blotting,Western Immunoblotting,Blot, Western,Immunoblot, Western,Western Blot,Western Immunoblot,Blots, Western,Blottings, Western,Immunoblots, Western,Immunoblottings, Western,Western Blots,Western Blottings,Western Immunoblots,Western Immunoblottings
D051858 Forkhead Transcription Factors A subclass of winged helix DNA-binding proteins that share homology with their founding member fork head protein, Drosophila. Forkhead Box Protein,Forkhead Box Transcription Factor,Forkhead Protein,Forkhead Transcription Factor,Forkhead Box Proteins,Forkhead Box Transcription Factors,Forkhead Proteins,Fox Transcription Factors,Box Protein, Forkhead,Box Proteins, Forkhead,Factor, Forkhead Transcription,Protein, Forkhead,Protein, Forkhead Box,Proteins, Forkhead Box,Transcription Factor, Forkhead,Transcription Factors, Forkhead,Transcription Factors, Fox
D017966 Pyramidal Cells Projection neurons in the CEREBRAL CORTEX and the HIPPOCAMPUS. Pyramidal cells have a pyramid-shaped soma with the apex and an apical dendrite pointed toward the pial surface and other dendrites and an axon emerging from the base. The axons may have local collaterals but also project outside their cortical region. Pyramidal Neurons,Cell, Pyramidal,Cells, Pyramidal,Neuron, Pyramidal,Neurons, Pyramidal,Pyramidal Cell,Pyramidal Neuron

Related Publications

Ki-Yeon Yoo, and Seung-Hae Kwon, and Choong Hyun Lee, and Bingchun Yan, and Joon Ha Park, and Ji Hyeon Ahn, and Jung Hoon Choi, and Taek Geun Ohk, and Jun Hwi Cho, and Moo-Ho Won
May 1995, Neuroscience letters,
Ki-Yeon Yoo, and Seung-Hae Kwon, and Choong Hyun Lee, and Bingchun Yan, and Joon Ha Park, and Ji Hyeon Ahn, and Jung Hoon Choi, and Taek Geun Ohk, and Jun Hwi Cho, and Moo-Ho Won
November 2005, Brain research,
Ki-Yeon Yoo, and Seung-Hae Kwon, and Choong Hyun Lee, and Bingchun Yan, and Joon Ha Park, and Ji Hyeon Ahn, and Jung Hoon Choi, and Taek Geun Ohk, and Jun Hwi Cho, and Moo-Ho Won
July 2016, Cellular and molecular neurobiology,
Ki-Yeon Yoo, and Seung-Hae Kwon, and Choong Hyun Lee, and Bingchun Yan, and Joon Ha Park, and Ji Hyeon Ahn, and Jung Hoon Choi, and Taek Geun Ohk, and Jun Hwi Cho, and Moo-Ho Won
February 2005, Neuroscience letters,
Ki-Yeon Yoo, and Seung-Hae Kwon, and Choong Hyun Lee, and Bingchun Yan, and Joon Ha Park, and Ji Hyeon Ahn, and Jung Hoon Choi, and Taek Geun Ohk, and Jun Hwi Cho, and Moo-Ho Won
May 2009, Neuroscience,
Ki-Yeon Yoo, and Seung-Hae Kwon, and Choong Hyun Lee, and Bingchun Yan, and Joon Ha Park, and Ji Hyeon Ahn, and Jung Hoon Choi, and Taek Geun Ohk, and Jun Hwi Cho, and Moo-Ho Won
March 2015, Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology,
Ki-Yeon Yoo, and Seung-Hae Kwon, and Choong Hyun Lee, and Bingchun Yan, and Joon Ha Park, and Ji Hyeon Ahn, and Jung Hoon Choi, and Taek Geun Ohk, and Jun Hwi Cho, and Moo-Ho Won
July 2017, Molecular medicine reports,
Ki-Yeon Yoo, and Seung-Hae Kwon, and Choong Hyun Lee, and Bingchun Yan, and Joon Ha Park, and Ji Hyeon Ahn, and Jung Hoon Choi, and Taek Geun Ohk, and Jun Hwi Cho, and Moo-Ho Won
June 2012, Brain research,
Ki-Yeon Yoo, and Seung-Hae Kwon, and Choong Hyun Lee, and Bingchun Yan, and Joon Ha Park, and Ji Hyeon Ahn, and Jung Hoon Choi, and Taek Geun Ohk, and Jun Hwi Cho, and Moo-Ho Won
March 1993, Neuropharmacology,
Ki-Yeon Yoo, and Seung-Hae Kwon, and Choong Hyun Lee, and Bingchun Yan, and Joon Ha Park, and Ji Hyeon Ahn, and Jung Hoon Choi, and Taek Geun Ohk, and Jun Hwi Cho, and Moo-Ho Won
March 1993, Neuroscience,
Copied contents to your clipboard!