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The antiviral effect of interferon inductors, such as poly-I--poly-C, phage f2 RNA replicative form and low molecular inductor GSN and their influence on cellular DNA synthesis were studied in the cultures of lymphoblastoid (inplanting lines Raji Namalva) and somatic human cells. The Semliki forest virus used as the test organism multiplicated well in cells Raji accumulating up to 9 lg BOU/ml. The two-strand RNA was less active in the lymphoid cells than in the somatic ones. GSN was 10 times more active and less toxic in cells Raji as compared to the fibroblasts. The lymphoblastoid interferon had higher antiviral activity as compared to the fibroblast interferon in the system of Raji--Semliki forest virus than in the system of the human embryon fibroblast--Venezuela Horse Encephalytic Virus. Romantadin actively inhibited (100 times) production of the alfavirus in both the somatic and lymphoblastoid cells.
A S Novokhatskiĭ, and
S S Labzo, and
A A Tsareva
January 1979,
Acta microbiologica Bulgarica,
A S Novokhatskiĭ, and
S S Labzo, and
A A Tsareva
January 1977,
Archives of virology,
A S Novokhatskiĭ, and
S S Labzo, and
A A Tsareva
June 1972,
CRC critical reviews in clinical laboratory sciences,
A S Novokhatskiĭ, and
S S Labzo, and
A A Tsareva
November 1979,
Virology,
A S Novokhatskiĭ, and
S S Labzo, and
A A Tsareva
July 1977,
Comprehensive therapy,
A S Novokhatskiĭ, and
S S Labzo, and
A A Tsareva
May 1979,
Molecular pharmacology,
A S Novokhatskiĭ, and
S S Labzo, and
A A Tsareva
November 1969,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
A S Novokhatskiĭ, and
S S Labzo, and
A A Tsareva
May 1983,
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society,
A S Novokhatskiĭ, and
S S Labzo, and
A A Tsareva
August 1979,
La Revue du praticien,
A S Novokhatskiĭ, and
S S Labzo, and
A A Tsareva
May 1974,
Environmental health perspectives,
