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The hemodynamic effects of epinephrine were prospectively studied in 13 patients with septic shock who remained hypotensive after both fluid loading and dopamine. Hemodynamic measurements were performed before and one hour after the start of epinephrine infusion. Systolic, diastolic, and mean arterial pressure increased in all patients (p less than 0.01). Cardiac index and systemic vascular resistance increased by 34 and 32 percent, respectively (p less than 0.05), but heart rate and pulmonary vascular resistance remained unchanged. There was a concomitant increase in oxygen delivery (p less than 0.01) and oxygen consumption (p less than 0.05), the magnitude of the latter being related to baseline lactacidemia (p less than 0.01). In view of the generally recognized physiologic goals of septic shock management, we conclude that epinephrine could be an appropriate alternative where fluid loading and dopamine have failed.
P E Bollaert, and
P Bauer, and
G Audibert, and
H Lambert, and
A Larcan
January 2001,
Critical care (London, England),
P E Bollaert, and
P Bauer, and
G Audibert, and
H Lambert, and
A Larcan
January 1982,
Sovetskaia meditsina,
P E Bollaert, and
P Bauer, and
G Audibert, and
H Lambert, and
A Larcan
November 2013,
Zhonghua er ke za zhi = Chinese journal of pediatrics,
P E Bollaert, and
P Bauer, and
G Audibert, and
H Lambert, and
A Larcan
January 2019,
European journal of pediatrics,
P E Bollaert, and
P Bauer, and
G Audibert, and
H Lambert, and
A Larcan
June 2003,
Critical care medicine,
P E Bollaert, and
P Bauer, and
G Audibert, and
H Lambert, and
A Larcan
September 1993,
Zhonghua wai ke za zhi [Chinese journal of surgery],
P E Bollaert, and
P Bauer, and
G Audibert, and
H Lambert, and
A Larcan
January 2015,
Zhonghua wei zhong bing ji jiu yi xue,
P E Bollaert, and
P Bauer, and
G Audibert, and
H Lambert, and
A Larcan
January 2019,
European journal of pediatrics,
P E Bollaert, and
P Bauer, and
G Audibert, and
H Lambert, and
A Larcan
April 2017,
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies,
P E Bollaert, and
P Bauer, and
G Audibert, and
H Lambert, and
A Larcan
August 1985,
Acta anaesthesiologica Scandinavica,
