Exploring the environmental and genetic etiologies of congenital heart defects: the Wisconsin Pediatric Cardiac Registry. 2011

Susan E Harris, and Christine Cronk, and Laura D Cassidy, and Pippa Simpson, and Aoy Tomita-Mitchell, and Andrew N Pelech
Medical College of Wisconsin, Department of Pediatrics, and Wisconsin Pediatric Cardiac Registry, Children's Hospital of Wisconsin, P.O. Box 1997, MS B550A, Milwaukee, WI 53201, USA.

BACKGROUND The Wisconsin Pediatric Cardiac Registry (WPCR) collects information on infants born in the state of Wisconsin with structural congenital heart disease (CHD). METHODS The WPCR actively ascertains CHD cases in the state of Wisconsin. Cases must be conceived and born in Wisconsin after January 1, 2000. Once ascertained, subjects are approached to participate in genetic sampling and completion of a questionnaire that assesses family history of CHD, maternal health, and environmental exposures before pregnancy and during the first trimester. In 2009, the WPCR underwent a transition to a new database and from a paper questionnaire to a Web-based questionnaire. RESULTS The WPCR has screened over 5,100 children and has ascertained 4,919 cases of CHD in the state of Wisconsin during the years 2000 to 2009. During this interval, 1,982 completed questionnaires and 1,062 DNA samples have been obtained from consented subjects. Another 1,774 DNA samples have been obtained from blood relatives of CHD subjects. CONCLUSIONS The WPCR operates as a specialized resource of genetic and environmental information on children with CHD for researchers focusing on the multifactorial causes of CHD.

UI MeSH Term Description Entries
D011795 Surveys and Questionnaires Collections of data obtained from voluntary subjects. The information usually takes the form of answers to questions, or suggestions. Community Survey,Nonrespondent,Questionnaire,Questionnaires,Respondent,Survey,Survey Method,Survey Methods,Surveys,Baseline Survey,Community Surveys,Methodology, Survey,Nonrespondents,Questionnaire Design,Randomized Response Technique,Repeated Rounds of Survey,Respondents,Survey Methodology,Baseline Surveys,Design, Questionnaire,Designs, Questionnaire,Methods, Survey,Questionnaire Designs,Questionnaires and Surveys,Randomized Response Techniques,Response Technique, Randomized,Response Techniques, Randomized,Survey, Baseline,Survey, Community,Surveys, Baseline,Surveys, Community,Techniques, Randomized Response
D012042 Registries The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers. Parish Registers,Population Register,Parish Register,Population Registers,Register, Parish,Register, Population,Registers, Parish,Registers, Population,Registry
D003219 Confidentiality The privacy of information and its protection against unauthorized disclosure. Patient Data Privacy,Privacy of Patient Data,Privileged Communication,Confidential Information,Secrecy,Communication, Privileged,Communications, Privileged,Data Privacy, Patient,Information, Confidential,Privacy, Patient Data,Privileged Communications
D006330 Heart Defects, Congenital Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life. Congenital Heart Disease,Heart Abnormalities,Abnormality, Heart,Congenital Heart Defect,Congenital Heart Defects,Defects, Congenital Heart,Heart Defect, Congenital,Heart, Malformation Of,Congenital Heart Diseases,Defect, Congenital Heart,Disease, Congenital Heart,Heart Abnormality,Heart Disease, Congenital,Malformation Of Heart,Malformation Of Hearts
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D014922 Wisconsin State bounded on the north by Lake Superior and Michigan, on the east by Lake Michigan, on the south by Illinois and Iowa, and on the west by Minnesota and Iowa.
D059019 Clinical Coding Process of substituting a symbol or code for a term such as a diagnosis or procedure. (from Slee's Health Care Terms, 3d ed.) Coding,Medical Coding,Coding, Clinical,Coding, Medical
D059647 Gene-Environment Interaction The combined effects of genotypes and environmental factors together on phenotypic characteristics. Environment-Gene Interaction,Environment Gene Interaction,Environment-Gene Interactions,Gene Environment Interaction,Gene-Environment Interactions,Interaction, Environment-Gene,Interaction, Gene-Environment,Interactions, Environment-Gene,Interactions, Gene-Environment
D020407 Internet A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange. World Wide Web,Cyber Space,Cyberspace,Web, World Wide,Wide Web, World

Related Publications

Susan E Harris, and Christine Cronk, and Laura D Cassidy, and Pippa Simpson, and Aoy Tomita-Mitchell, and Andrew N Pelech
May 2006, WMJ : official publication of the State Medical Society of Wisconsin,
Susan E Harris, and Christine Cronk, and Laura D Cassidy, and Pippa Simpson, and Aoy Tomita-Mitchell, and Andrew N Pelech
January 2020, Advances in experimental medicine and biology,
Susan E Harris, and Christine Cronk, and Laura D Cassidy, and Pippa Simpson, and Aoy Tomita-Mitchell, and Andrew N Pelech
November 2017, World journal for pediatric & congenital heart surgery,
Susan E Harris, and Christine Cronk, and Laura D Cassidy, and Pippa Simpson, and Aoy Tomita-Mitchell, and Andrew N Pelech
January 2007, Archivos de cardiologia de Mexico,
Susan E Harris, and Christine Cronk, and Laura D Cassidy, and Pippa Simpson, and Aoy Tomita-Mitchell, and Andrew N Pelech
December 1993, The Annals of thoracic surgery,
Susan E Harris, and Christine Cronk, and Laura D Cassidy, and Pippa Simpson, and Aoy Tomita-Mitchell, and Andrew N Pelech
January 2006, AMIA ... Annual Symposium proceedings. AMIA Symposium,
Susan E Harris, and Christine Cronk, and Laura D Cassidy, and Pippa Simpson, and Aoy Tomita-Mitchell, and Andrew N Pelech
January 2004, WMJ : official publication of the State Medical Society of Wisconsin,
Susan E Harris, and Christine Cronk, and Laura D Cassidy, and Pippa Simpson, and Aoy Tomita-Mitchell, and Andrew N Pelech
May 2000, Circulation research,
Susan E Harris, and Christine Cronk, and Laura D Cassidy, and Pippa Simpson, and Aoy Tomita-Mitchell, and Andrew N Pelech
July 2011, Birth defects research. Part A, Clinical and molecular teratology,
Susan E Harris, and Christine Cronk, and Laura D Cassidy, and Pippa Simpson, and Aoy Tomita-Mitchell, and Andrew N Pelech
January 1986, Revista chilena de pediatria,
Copied contents to your clipboard!