BIOMAT Database Logo BIOMAT Database Logo

Synthesis, X-ray crystal structure, DNA binding, antioxidant and cytotoxicity studies of Ni(ii) and Pd(ii) thiosemicarbazone complexes. 2012

Eswaran Ramachandran, and Palaniappan Kalaivani, and Rathinasabapathi Prabhakaran, and Nigam P Rath, and Selvaraj Brinda, and Paramasivan Poornima, and Viswanatha Vijaya Padma, and Karuppannan Natarajan
Department of Chemistry, Bharathiar University, Coimbatore, 641 046, India.

New complexes, [Ni(HL)(PPh(3))]Cl (1), [Pd(L)(PPh(3))](2), and [Pd(L)(AsPh(3))](3), were synthesized from the reactions of 4-chloro-5-methyl-salicylaldehyde thiosemicarbazone [H(2)L] with [NiCl(2)(PPh(3))(2)], [PdCl(2)(PPh(3))(2)] and [PdCl(2)(AsPh(3))(2)]. They were characterized by IR, electronic, (1)H-NMR spectral data. Further, the structures of the complexes have been determined by single crystal X-ray diffraction. While the thiosemicarbazone coordinated as binegative tridentate (ONS) in complexes 2 and 3, it is coordinated as mono negative tridentate (ONS) in 1. The interactions of the new complexes with calf thymus DNA was examined by absorption and emission spectra, and viscosity measurements. Moreover, the antioxidant properties of the new complexes have also been tested against DPPH radical in which complex 1 exhibited better activity than that of the other two complexes 2 and 3. The in vitro cytotoxicity of complexes 1-3 against A549 and HepG2 cell lines was assayed, and the new complexes exhibited higher cytotoxic activity with lower IC(50) values indicating their efficiency in killing the cancer cells even at very low concentrations.

UI MeSH Term Description Entries
D007770 L-Lactate Dehydrogenase A tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of LACTATE and PYRUVATE. In vertebrates, genes for three different subunits (LDH-A, LDH-B and LDH-C) exist. Lactate Dehydrogenase,Dehydrogenase, L-Lactate,Dehydrogenase, Lactate,L Lactate Dehydrogenase
D008958 Models, Molecular Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures. Molecular Models,Model, Molecular,Molecular Model
D009532 Nickel A trace element with the atomic symbol Ni, atomic number 28, and atomic weight 58.69. It is a cofactor of the enzyme UREASE.
D009569 Nitric Oxide A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP. Endogenous Nitrate Vasodilator,Mononitrogen Monoxide,Nitric Oxide, Endothelium-Derived,Nitrogen Monoxide,Endothelium-Derived Nitric Oxide,Monoxide, Mononitrogen,Monoxide, Nitrogen,Nitrate Vasodilator, Endogenous,Nitric Oxide, Endothelium Derived,Oxide, Nitric,Vasodilator, Endogenous Nitrate
D010165 Palladium A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.
D010851 Picrates Salts or esters of PICRIC ACID.
D002417 Cattle Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor. Beef Cow,Bos grunniens,Bos indicus,Bos indicus Cattle,Bos taurus,Cow,Cow, Domestic,Dairy Cow,Holstein Cow,Indicine Cattle,Taurine Cattle,Taurus Cattle,Yak,Zebu,Beef Cows,Bos indicus Cattles,Cattle, Bos indicus,Cattle, Indicine,Cattle, Taurine,Cattle, Taurus,Cattles, Bos indicus,Cattles, Indicine,Cattles, Taurine,Cattles, Taurus,Cow, Beef,Cow, Dairy,Cow, Holstein,Cows,Dairy Cows,Domestic Cow,Domestic Cows,Indicine Cattles,Taurine Cattles,Taurus Cattles,Yaks,Zebus
D002460 Cell Line Established cell cultures that have the potential to propagate indefinitely. Cell Lines,Line, Cell,Lines, Cell
D002470 Cell Survival The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability. Cell Viability,Cell Viabilities,Survival, Cell,Viabilities, Cell,Viability, Cell
D004247 DNA A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine). DNA, Double-Stranded,Deoxyribonucleic Acid,ds-DNA,DNA, Double Stranded,Double-Stranded DNA,ds DNA

Related Publications

Eswaran Ramachandran, and Palaniappan Kalaivani, and Rathinasabapathi Prabhakaran, and Nigam P Rath, and Selvaraj Brinda, and Paramasivan Poornima, and Viswanatha Vijaya Padma, and Karuppannan Natarajan
Synthesis, X-ray crystal structure, DNA/BSA binding, DNA cleavage and cytotoxicity studies of phenanthroline based copper(II)/zinc(II) complexes.
August 2017, Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine,
Eswaran Ramachandran, and Palaniappan Kalaivani, and Rathinasabapathi Prabhakaran, and Nigam P Rath, and Selvaraj Brinda, and Paramasivan Poornima, and Viswanatha Vijaya Padma, and Karuppannan Natarajan
DNA binding, antioxidant, cytotoxicity (MTT, lactate dehydrogenase, NO), and cellular uptake studies of structurally different nickel(II) thiosemicarbazone complexes: synthesis, spectroscopy, electrochemistry, and X-ray crystallography.
February 2013, Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry,
Eswaran Ramachandran, and Palaniappan Kalaivani, and Rathinasabapathi Prabhakaran, and Nigam P Rath, and Selvaraj Brinda, and Paramasivan Poornima, and Viswanatha Vijaya Padma, and Karuppannan Natarajan
Synthesis, X-ray structure and in vitro cytotoxicity studies of Cu(I/II) complexes of thiosemicarbazone: special emphasis on their interactions with DNA.
April 2015, Dalton transactions (Cambridge, England : 2003),
Eswaran Ramachandran, and Palaniappan Kalaivani, and Rathinasabapathi Prabhakaran, and Nigam P Rath, and Selvaraj Brinda, and Paramasivan Poornima, and Viswanatha Vijaya Padma, and Karuppannan Natarajan
Synthesis, X-ray crystal structure, DNA/protein binding and cytotoxicity studies of five α-aminophosphonate N-derivatives.
December 2016, Bioorganic chemistry,
Eswaran Ramachandran, and Palaniappan Kalaivani, and Rathinasabapathi Prabhakaran, and Nigam P Rath, and Selvaraj Brinda, and Paramasivan Poornima, and Viswanatha Vijaya Padma, and Karuppannan Natarajan
Polynuclear zinc(II) complexes of thiosemicarbazone: Synthesis, X-ray structure and biological evaluation.
February 2020, Journal of inorganic biochemistry,
Eswaran Ramachandran, and Palaniappan Kalaivani, and Rathinasabapathi Prabhakaran, and Nigam P Rath, and Selvaraj Brinda, and Paramasivan Poornima, and Viswanatha Vijaya Padma, and Karuppannan Natarajan
Synthesis, crystal structure, DNA-binding and cytotoxicity in vitro of novel cis-Pt(II) and trans-Pd(II) pyridine carboxamide complexes.
December 2010, Bioorganic & medicinal chemistry letters,
Eswaran Ramachandran, and Palaniappan Kalaivani, and Rathinasabapathi Prabhakaran, and Nigam P Rath, and Selvaraj Brinda, and Paramasivan Poornima, and Viswanatha Vijaya Padma, and Karuppannan Natarajan
Diorganotin complexes of a thiosemicarbazone, synthesis: properties, x-ray crystal structure, and antiproliferative activity of diorganotin complexes.
January 2010, Bioinorganic chemistry and applications,
Eswaran Ramachandran, and Palaniappan Kalaivani, and Rathinasabapathi Prabhakaran, and Nigam P Rath, and Selvaraj Brinda, and Paramasivan Poornima, and Viswanatha Vijaya Padma, and Karuppannan Natarajan
Synthesis, crystal structure, DNA binding and in vitro biological studies of Ni(II), Cu(II) and Zn(II) complexes of N-phthaloylglycine.
December 2012, Journal of photochemistry and photobiology. B, Biology,
Eswaran Ramachandran, and Palaniappan Kalaivani, and Rathinasabapathi Prabhakaran, and Nigam P Rath, and Selvaraj Brinda, and Paramasivan Poornima, and Viswanatha Vijaya Padma, and Karuppannan Natarajan
Synthesis, crystal structure, cytotoxicity, in-detail experimental and computational CT-DNA interaction studies of 2-picolinate Pd(II) and Pt(II) complexes.
August 2023, Journal of biomolecular structure & dynamics,
Eswaran Ramachandran, and Palaniappan Kalaivani, and Rathinasabapathi Prabhakaran, and Nigam P Rath, and Selvaraj Brinda, and Paramasivan Poornima, and Viswanatha Vijaya Padma, and Karuppannan Natarajan
Synthesis, characterization, cellular uptake, apoptosis, cytotoxicity, dna-binding, and antioxidant activity studies of ruthenium(II) complexes.
January 2012, Nucleosides, nucleotides & nucleic acids,
Copied contents to your clipboard!