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The aim of this study was to evaluate the effects of topical application of simvastatin gel (7.5 mg) on the removal torque of titanium implants in the rabbit tibia. A total of 32 surgeries were performed on 16 New Zealand rabbits for the placement of 2 implants in 1 tibia of each rabbit. Only 1 of the surgical defects was injected with 30 mg/mL of simvastatin gel before implant placement. The initial torque was set at 20 N.cm, and removal torque testing was performed 28 and 56 days postoperatively with a Tonishi torque wrench. Surgical defects were divided into 4 groups: group IG-28 (test, 28 days), group IG-56 (test, 56 days), group I-28 (control, 28 days), and group I-56 (control, 56 days). Removal torque values were higher in group IG-56 than in groups IG-28, I-28, and I-56 (P < .05). Groups IG-28, I-28, and I-56 showed similar values (P > .05). Removal torque force increased under the influence of simvastatin, indicating that topical administration of a 7.5-mg dose of simvastatin gel is effective in improving the torque force required to remove implants inserted in the rabbit tibia.
Fatima Neves Faraco-Schwed, and
Luiz Macedo Mangueira, and
Joao Vitor Albuquerque Ribeiro, and
Alexsandro Da Silva Antao, and
Jamil Awad Shibli
November 2003,
Biomaterials,
Fatima Neves Faraco-Schwed, and
Luiz Macedo Mangueira, and
Joao Vitor Albuquerque Ribeiro, and
Alexsandro Da Silva Antao, and
Jamil Awad Shibli
September 2003,
Biomaterials,
Fatima Neves Faraco-Schwed, and
Luiz Macedo Mangueira, and
Joao Vitor Albuquerque Ribeiro, and
Alexsandro Da Silva Antao, and
Jamil Awad Shibli
July 2008,
American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics,
Fatima Neves Faraco-Schwed, and
Luiz Macedo Mangueira, and
Joao Vitor Albuquerque Ribeiro, and
Alexsandro Da Silva Antao, and
Jamil Awad Shibli
January 1987,
The International journal of oral & maxillofacial implants,
Fatima Neves Faraco-Schwed, and
Luiz Macedo Mangueira, and
Joao Vitor Albuquerque Ribeiro, and
Alexsandro Da Silva Antao, and
Jamil Awad Shibli
January 2014,
Platelets,
Fatima Neves Faraco-Schwed, and
Luiz Macedo Mangueira, and
Joao Vitor Albuquerque Ribeiro, and
Alexsandro Da Silva Antao, and
Jamil Awad Shibli
January 2000,
The International journal of oral & maxillofacial implants,
Fatima Neves Faraco-Schwed, and
Luiz Macedo Mangueira, and
Joao Vitor Albuquerque Ribeiro, and
Alexsandro Da Silva Antao, and
Jamil Awad Shibli
January 1981,
Rivista italiana di stomatologia,
Fatima Neves Faraco-Schwed, and
Luiz Macedo Mangueira, and
Joao Vitor Albuquerque Ribeiro, and
Alexsandro Da Silva Antao, and
Jamil Awad Shibli
January 1991,
Clinical oral implants research,
Fatima Neves Faraco-Schwed, and
Luiz Macedo Mangueira, and
Joao Vitor Albuquerque Ribeiro, and
Alexsandro Da Silva Antao, and
Jamil Awad Shibli
January 2007,
International journal of immunopathology and pharmacology,
Fatima Neves Faraco-Schwed, and
Luiz Macedo Mangueira, and
Joao Vitor Albuquerque Ribeiro, and
Alexsandro Da Silva Antao, and
Jamil Awad Shibli
January 2010,
Indian journal of dental research : official publication of Indian Society for Dental Research,
