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The potent tumor promoter, 12-O-tetradecanoylphorbol-13-acetate, produced a 2- to 3-fold increase in the activity of both the low- and high-affinity forms of cyclic adenosine 3':5'-monophosphate phosphodiesterase activity 13 hr after application to mouse skin. The magnitude of the enzyme induction correlated with the tumor-promoting activity of several doses of 12-O-tetradecanoylphorbol-13-acetate and of other phorbol esters. The induction of the low-affinity phosphodiesterase could be blocked by prior i.p. injection of the microtubule poisons, colchicine and vinblastine. The low-affinity cyclic adenosine 3':5'-monophosphate phosphodiesterase activity of the epidermal component of mouse skin papillomas produced by two-stage tumorigenesis was 3 times that of the surrounding uninvolved epidermis.
R A Mufson, and
R C Simsiman, and
R K Boutwell
January 1975,
Cancer research,
R A Mufson, and
R C Simsiman, and
R K Boutwell
January 1976,
Cancer research,
R A Mufson, and
R C Simsiman, and
R K Boutwell
November 1980,
Hoppe-Seyler's Zeitschrift fur physiologische Chemie,
R A Mufson, and
R C Simsiman, and
R K Boutwell
January 1975,
Journal of the National Cancer Institute,
R A Mufson, and
R C Simsiman, and
R K Boutwell
February 1972,
The British journal of dermatology,
R A Mufson, and
R C Simsiman, and
R K Boutwell
December 1970,
The Biochemical journal,
R A Mufson, and
R C Simsiman, and
R K Boutwell
December 1973,
Proceedings of the National Academy of Sciences of the United States of America,
R A Mufson, and
R C Simsiman, and
R K Boutwell
July 1972,
Proceedings of the National Academy of Sciences of the United States of America,
R A Mufson, and
R C Simsiman, and
R K Boutwell
January 1975,
Biochemical Society transactions,
R A Mufson, and
R C Simsiman, and
R K Boutwell
January 1973,
Biochemical pharmacology,
