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Successful Handling of Disseminated BCG Disease in a Child with Severe Combined Immunodeficiency. 2011
Sílvia Bacalhau, and
Cristina Freitas, and
Rosalina Valente, and
Deolinda Barata, and
Conceição Neves, and
Katrin Schäfer, and
Annelie Lubatschofski, and
Ansgar Schulz, and
João Farela Neves
Pediatric Intensive Care Unit, Hospital Dona Estefânia, 1169-045 Lisboa, Portugal.
In high-burden countries, Mycobacterium bovis Bacillus Calmette-Guérin (BCG) vaccine is administered in newborn to prevent severe Mycobacterium tuberculosis infection. Because life-threatening disseminated BCG disease may occur in children with primary immunodeficiency, vaccination strategy against tuberculosis should be redefined in non-high-burden countries. We report the case of a patient with X-linked severe combined immunodeficiency (SCID) who developed disseminated BCG disease, highlighting the specific strategies adopted.
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