-transparent.png){kind=logo}
The skin penetration of roxithromycin was studied in 27 surgical patients treated with 300 mg orally followed by three oral doses of 150 mg 12-hourly. Peak plasma and skin concentrations of 7.9 +/- 1.2 mg/l and 31.3 +/- 3.7 mg/kg occurred 2.5 and 4 h after last dosing respectively. The plasma and skin half-lives were 7.7 and 6.0 h, and the mean plasma and skin area under the curve values were 64.3 mg/l.h and 155.3 mg/kg.h. Skin/plasma concentration ratios were 4.9 +/- 0.5, 9.7 +/- 1.2, 7.6 +/- 0.8 and 5.9 +/- 1.1, at 3, 4, 5 and 6 h after last dosing respectively. These results demonstrate that roxithromycin achieves high levels in human skin.
Related Publications
M Campa, and
I Zolfino, and
S Senesi, and
N Bernardini, and
R Danesi, and
M Ducci, and
M Oleggini, and
R Di Stefano, and
F Mosca, and
A Lazzarini
January 1992,
Diagnostic microbiology and infectious disease,
M Campa, and
I Zolfino, and
S Senesi, and
N Bernardini, and
R Danesi, and
M Ducci, and
M Oleggini, and
R Di Stefano, and
F Mosca, and
A Lazzarini
January 1991,
Chemotherapy,
M Campa, and
I Zolfino, and
S Senesi, and
N Bernardini, and
R Danesi, and
M Ducci, and
M Oleggini, and
R Di Stefano, and
F Mosca, and
A Lazzarini
July 1989,
Journal of chemotherapy (Florence, Italy),
M Campa, and
I Zolfino, and
S Senesi, and
N Bernardini, and
R Danesi, and
M Ducci, and
M Oleggini, and
R Di Stefano, and
F Mosca, and
A Lazzarini
April 1976,
Die Pharmazie,
M Campa, and
I Zolfino, and
S Senesi, and
N Bernardini, and
R Danesi, and
M Ducci, and
M Oleggini, and
R Di Stefano, and
F Mosca, and
A Lazzarini
January 2013,
Current pharmaceutical design,
M Campa, and
I Zolfino, and
S Senesi, and
N Bernardini, and
R Danesi, and
M Ducci, and
M Oleggini, and
R Di Stefano, and
F Mosca, and
A Lazzarini
December 2004,
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete,
M Campa, and
I Zolfino, and
S Senesi, and
N Bernardini, and
R Danesi, and
M Ducci, and
M Oleggini, and
R Di Stefano, and
F Mosca, and
A Lazzarini
October 2008,
Antimicrobial agents and chemotherapy,
M Campa, and
I Zolfino, and
S Senesi, and
N Bernardini, and
R Danesi, and
M Ducci, and
M Oleggini, and
R Di Stefano, and
F Mosca, and
A Lazzarini
October 1957,
The Journal of investigative dermatology,
M Campa, and
I Zolfino, and
S Senesi, and
N Bernardini, and
R Danesi, and
M Ducci, and
M Oleggini, and
R Di Stefano, and
F Mosca, and
A Lazzarini
July 1946,
The Journal of general physiology,
M Campa, and
I Zolfino, and
S Senesi, and
N Bernardini, and
R Danesi, and
M Ducci, and
M Oleggini, and
R Di Stefano, and
F Mosca, and
A Lazzarini
January 1984,
Dermatologische Monatschrift,
