-transparent.png){kind=logo}
NB-598, (E)N-ethyl-N-(6,6-dimethyl-2-hepten-4-ynyl)-3-[(3,3'-bith iophen-5-yl)methoxy]benzene-methanamine, was found to inhibit human microsomal squalene epoxidase (from Hep G2 cells) in a competitive manner. NB-598 inhibited cholesterol synthesis from [14C]acetate dose dependently in Hep G2 cells and increased the intracellular radioactivity of squalene. A single oral administration of NB-598 inhibited cholesterol synthesis from [14C]acetate in rats. Moreover, multiple oral administration of NB-598 to dogs decreased serum total and low density lipoprotein cholesterol levels and increased serum squalene levels. After termination of treatment, the reduced serum cholesterol and increased squalene levels returned to their control values.
M Horie, and
Y Tsuchiya, and
M Hayashi, and
Y Iida, and
Y Iwasawa, and
Y Nagata, and
Y Sawasaki, and
H Fukuzumi, and
K Kitani, and
T Kamei
February 1992,
Chemical & pharmaceutical bulletin,
M Horie, and
Y Tsuchiya, and
M Hayashi, and
Y Iida, and
Y Iwasawa, and
Y Nagata, and
Y Sawasaki, and
H Fukuzumi, and
K Kitani, and
T Kamei
July 1991,
The Journal of biological chemistry,
M Horie, and
Y Tsuchiya, and
M Hayashi, and
Y Iida, and
Y Iwasawa, and
Y Nagata, and
Y Sawasaki, and
H Fukuzumi, and
K Kitani, and
T Kamei
July 1993,
Biochemical pharmacology,
M Horie, and
Y Tsuchiya, and
M Hayashi, and
Y Iida, and
Y Iwasawa, and
Y Nagata, and
Y Sawasaki, and
H Fukuzumi, and
K Kitani, and
T Kamei
May 1993,
Biochimica et biophysica acta,
M Horie, and
Y Tsuchiya, and
M Hayashi, and
Y Iida, and
Y Iwasawa, and
Y Nagata, and
Y Sawasaki, and
H Fukuzumi, and
K Kitani, and
T Kamei
November 2001,
European journal of pharmacology,
M Horie, and
Y Tsuchiya, and
M Hayashi, and
Y Iida, and
Y Iwasawa, and
Y Nagata, and
Y Sawasaki, and
H Fukuzumi, and
K Kitani, and
T Kamei
February 2000,
Biochemical and biophysical research communications,
M Horie, and
Y Tsuchiya, and
M Hayashi, and
Y Iida, and
Y Iwasawa, and
Y Nagata, and
Y Sawasaki, and
H Fukuzumi, and
K Kitani, and
T Kamei
February 2004,
Bioorganic & medicinal chemistry letters,
M Horie, and
Y Tsuchiya, and
M Hayashi, and
Y Iida, and
Y Iwasawa, and
Y Nagata, and
Y Sawasaki, and
H Fukuzumi, and
K Kitani, and
T Kamei
April 2000,
Biochemical and biophysical research communications,
M Horie, and
Y Tsuchiya, and
M Hayashi, and
Y Iida, and
Y Iwasawa, and
Y Nagata, and
Y Sawasaki, and
H Fukuzumi, and
K Kitani, and
T Kamei
June 1972,
The Journal of biological chemistry,
M Horie, and
Y Tsuchiya, and
M Hayashi, and
Y Iida, and
Y Iwasawa, and
Y Nagata, and
Y Sawasaki, and
H Fukuzumi, and
K Kitani, and
T Kamei
October 2013,
ACS medicinal chemistry letters,
