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We investigated immunohistochemical expressions of the epidermal growth factor (EGF) and the epidermal growth factor receptor (EGFR) in 25 cases of pancreatic carcinoma, including 13 cases of metastatic lymph nodes. EGF and EGFR were stained mainly in the cytoplasm and on the surface of some pancreatic carcinoma cells, with positive rates of 18/25 (72%) and 9/25 (36%) respectively. In all cases EGFR was noted only when EGF was also detected. EGF and EGFR were stained frequently in differentiated types. In metastatic lymph nodes, EGF and EGFR were found in 54% and 15% respectively, and they were detected only when they were also noted in the same patient's primary lesions. EGF and EGFR were found more frequently in Stages III and IV than in Stage II. These results emphasize that EGF and EGFR may promote both the proliferation and the differentiation of human pancreatic carcinoma cells, as in other sites.
Y Yamanaka, and
M Onda, and
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T Kobayashi, and
K Sasajima, and
A Tokunaga, and
T Tajiri, and
K Egami, and
G Asano
April 1989,
Cancer,
Y Yamanaka, and
M Onda, and
E Uchida, and
T Kobayashi, and
K Sasajima, and
A Tokunaga, and
T Tajiri, and
K Egami, and
G Asano
March 1994,
Oncology reports,
Y Yamanaka, and
M Onda, and
E Uchida, and
T Kobayashi, and
K Sasajima, and
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T Tajiri, and
K Egami, and
G Asano
January 1988,
Archivio italiano di anatomia e di embriologia. Italian journal of anatomy and embryology,
Y Yamanaka, and
M Onda, and
E Uchida, and
T Kobayashi, and
K Sasajima, and
A Tokunaga, and
T Tajiri, and
K Egami, and
G Asano
May 1990,
Pancreas,
Y Yamanaka, and
M Onda, and
E Uchida, and
T Kobayashi, and
K Sasajima, and
A Tokunaga, and
T Tajiri, and
K Egami, and
G Asano
June 1988,
Nihon Geka Gakkai zasshi,
Y Yamanaka, and
M Onda, and
E Uchida, and
T Kobayashi, and
K Sasajima, and
A Tokunaga, and
T Tajiri, and
K Egami, and
G Asano
January 2022,
Journal of oral and maxillofacial pathology : JOMFP,
Y Yamanaka, and
M Onda, and
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K Sasajima, and
A Tokunaga, and
T Tajiri, and
K Egami, and
G Asano
February 1991,
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Y Yamanaka, and
M Onda, and
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G Asano
January 1999,
Pathology oncology research : POR,
Y Yamanaka, and
M Onda, and
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T Kobayashi, and
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A Tokunaga, and
T Tajiri, and
K Egami, and
G Asano
March 1988,
Nihon Geka Gakkai zasshi,
Y Yamanaka, and
M Onda, and
E Uchida, and
T Kobayashi, and
K Sasajima, and
A Tokunaga, and
T Tajiri, and
K Egami, and
G Asano
May 1990,
Cancer,
