BIOMAT Database Logo BIOMAT Database Logo

Olmesartan medoxomil is associated with decreased plasma AGEs, pentosidine, and N-(epsilon)-carboxymethyl-lysine levels in hemodialysis patients. 2012

Hirokazu Honda, and Nozomu Hosaka, and Yumie Aoshima, and Yuki Hirai, and Tetsuo Michihata, and Tadao Akizawa
Department of Medicine, Showa University School of Medicine, Shinagawa-ku, Tokyo, Japan. hondah@med.showa-u.ac.jp

BACKGROUND Advanced glycation end products (AGEs) are associated with comorbidity and death among patients on hemodialysis (HD). Angiotensin II type 1 receptor blockers (ARBs) can decrease the formation of AGEs in vitro. This study examines the ability of various ARBs to decrease plasma AGE levels in hypertensive patients on HD. METHODS This preliminary randomized prospective study included 24 hypertensive patients on HD who were treated with candesartan (8 mg/day). The patients were randomly assigned to an olmesartan (20 mg/day, n = 12) or a telmisartan (40 mg/day, n = 12) group and followed up 24 weeks. Blood pressure was monitored before each HD session, and plasma pentosidine, N-(epsilon)-carboxymethyl-lysine (CML), serum malondialdehyde-low-density lipoprotein (LDL), high-sensitive CRP, and serum total free radical (TFR) were measured at baseline, and at 4, 12, and 24 weeks. RESULTS Olmesartan was significantly associated with decreased systolic blood pressure compared with telmisartan. After 24 weeks of treatment, plasma pentosidine and CML levels were significantly decreased and serum TFR levels tended to be decreased in the olmesartan group, but remained unchanged in the telmisartan group. CONCLUSIONS These results suggest that olmesartan can help to decrease plasma AGE levels in patients on HD.

UI MeSH Term Description Entries
D006977 Hypertension, Renal Persistent high BLOOD PRESSURE due to KIDNEY DISEASES, such as those involving the renal parenchyma, the renal vasculature, or tumors that secrete RENIN. Hypertensions, Renal,Renal Hypertension,Renal Hypertensions
D007093 Imidazoles Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).
D007249 Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function. Innate Inflammatory Response,Inflammations,Inflammatory Response, Innate,Innate Inflammatory Responses
D007676 Kidney Failure, Chronic The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION. ESRD,End-Stage Renal Disease,Renal Disease, End-Stage,Renal Failure, Chronic,Renal Failure, End-Stage,Chronic Kidney Failure,End-Stage Kidney Disease,Chronic Renal Failure,Disease, End-Stage Kidney,Disease, End-Stage Renal,End Stage Kidney Disease,End Stage Renal Disease,End-Stage Renal Failure,Kidney Disease, End-Stage,Renal Disease, End Stage,Renal Failure, End Stage
D008239 Lysine An essential amino acid. It is often added to animal feed. Enisyl,L-Lysine,Lysine Acetate,Lysine Hydrochloride,Acetate, Lysine,L Lysine
D008297 Male Males
D010865 Pilot Projects Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work. Pilot Studies,Pilot Study,Pilot Project,Project, Pilot,Projects, Pilot,Studies, Pilot,Study, Pilot
D011446 Prospective Studies Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group. Prospective Study,Studies, Prospective,Study, Prospective
D001794 Blood Pressure PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS. Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D005260 Female Females

Related Publications

Hirokazu Honda, and Nozomu Hosaka, and Yumie Aoshima, and Yuki Hirai, and Tetsuo Michihata, and Tadao Akizawa
Olmesartan medoxomil treatment is associated with decreased plasma B-type natriuretic peptide levels in patients on hemodialysis.
January 2012, Clinical and experimental hypertension (New York, N.Y. : 1993),
Hirokazu Honda, and Nozomu Hosaka, and Yumie Aoshima, and Yuki Hirai, and Tetsuo Michihata, and Tadao Akizawa
Pentosidine and N(epsilon)-(carboxymethyl)-lysine in Alzheimer's disease and vascular dementia.
January 2003, Neurobiology of aging,
Hirokazu Honda, and Nozomu Hosaka, and Yumie Aoshima, and Yuki Hirai, and Tetsuo Michihata, and Tadao Akizawa
Influence of icodextrin on plasma and dialysate levels of N(epsilon)-(carboxymethyl)lysine and N(epsilon)-(carboxyethyl)lysine.
January 2005, Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis,
Hirokazu Honda, and Nozomu Hosaka, and Yumie Aoshima, and Yuki Hirai, and Tetsuo Michihata, and Tadao Akizawa
Effect of medium cut-off membranes on Pentosidine and N-(carboxymethyl) lysine levels in uncontrolled diabetic hemodialysis patients.
April 2024, Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy,
Hirokazu Honda, and Nozomu Hosaka, and Yumie Aoshima, and Yuki Hirai, and Tetsuo Michihata, and Tadao Akizawa
Immunohistochemical detection of imidazolone and N(epsilon)-(carboxymethyl)lysine in aortas of hemodialysis patients.
November 1998, Cellular and molecular biology (Noisy-le-Grand, France),
Hirokazu Honda, and Nozomu Hosaka, and Yumie Aoshima, and Yuki Hirai, and Tetsuo Michihata, and Tadao Akizawa
Plasma N-epsilon-(carboxymethyl)lysine levels are associated with the extent of vessel injury after coronary arterial stenting.
August 2008, Coronary artery disease,
Hirokazu Honda, and Nozomu Hosaka, and Yumie Aoshima, and Yuki Hirai, and Tetsuo Michihata, and Tadao Akizawa
N(epsilon)-(carboxymethyl)lysine levels in patients with type 2 diabetes: role of renal function.
October 2001, American journal of kidney diseases : the official journal of the National Kidney Foundation,
Hirokazu Honda, and Nozomu Hosaka, and Yumie Aoshima, and Yuki Hirai, and Tetsuo Michihata, and Tadao Akizawa
Involvement of advanced glycation end-products, pentosidine and N(epsilon)-(carboxymethyl)lysine, in doxorubicin-induced cardiomyopathy in rats.
January 2010, Toxicology,
Hirokazu Honda, and Nozomu Hosaka, and Yumie Aoshima, and Yuki Hirai, and Tetsuo Michihata, and Tadao Akizawa
Accumulation of imidazolone, pentosidine and N(epsilon)-(carboxymethyl)lysine in hippocampal CA4 pyramidal neurons of aged human brain.
September 2002, Pathology international,
Hirokazu Honda, and Nozomu Hosaka, and Yumie Aoshima, and Yuki Hirai, and Tetsuo Michihata, and Tadao Akizawa
Serum N-epsilon-(carboxymethyl)lysine is elevated in nondiabetic coronary heart disease patients.
January 2002, Journal of basic and clinical physiology and pharmacology,
Copied contents to your clipboard!