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Crystal and solution structures of the oligonucleotide d(ATGCGCAT)2: a combined X-ray and NMR study. 1990
G R Clark, and
D G Brown, and
M R Sanderson, and
T Chwalinski, and
S Neidle, and
J M Veal, and
R L Jones, and
W D Wilson, and
G Zon, and
E Garman
Cancer Research Campaign Biomolecular Structure Unit, Institute of Cancer Research, Sutton, Surrey, UK.
A combined crystal-structure determination and NMR analysis of the octanucleotide d(ATGCGCAT)2 is reported. The X-ray analysis shows that the structure is A-form duplex in crystal state. The NMR study shows that in solution this sequence is B-type. The conformational results from each technique are presented in detail. The implications of these findings in terms of conformational flexibility and ligand binding are discussed.
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G Zon, and
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J M Veal, and
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E Garman
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