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The radiological finding of a large sella turcica in long standing peripheral endocrine insufficiency (adrenocortical in one case, thyroid in the other) and the persistence of plasma ACTH and TSH levels above normal despite hormone therapy was first attributed to the consequences of reactive hypersecretion of the corresponding stimulin. The results of scanner studies in one case, and of pathological examination in the other, revealed the presence of primary empty sella syndrom.
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