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Penetration of 50 muCi of [3H]T-2 mycotoxin through abraded and intact skin was studied in anesthetized rats sacrificed at 5, 15, 30, 45, 60 and 90 min post-exposure. The greatest penetration was through abraded skin (49 +/- 7%) at 90 min post-exposure, whereas penetration through intact skin (2 +/- 3%) was substantially less (P less than 0.0015). Methods to decontaminate [3H]T-2 mycotoxin from abraded skin over time were studied. Treatment of [3H]T-2 contaminated abrasions by applying Trau + Medic dressing, applying Charcoal Cloth-Anti-bacterial Field Dressing (Charcoal Dressing), or swabbing with povidone-iodine 30 min post-exposure removed 17-32% of the applied [3H]T-2. Immediate blotting with immediate removal of the dressings absorbed 103 +/- 4% (Trau + Medic) and 87 +/- 4% (Charcoal Dressing) of the applied [3H]T-2, while immediate blotting and leaving the dressing in place for 30 min removed 91 +/- 5% (Trau + Medic) and 76 +/- 3% (Charcoal Dressing). It appears that immediate blotting with either dressing followed by immediate removal before application of a clean dressing is an effective method for decontaminating [3H]T-2 from abrasions.
V B Solberg, and
F H Broski, and
R E Dinterman, and
D T George
December 1984,
Zhongguo yao li xue bao = Acta pharmacologica Sinica,
V B Solberg, and
F H Broski, and
R E Dinterman, and
D T George
November 1984,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
V B Solberg, and
F H Broski, and
R E Dinterman, and
D T George
January 2008,
Skin pharmacology and physiology,
V B Solberg, and
F H Broski, and
R E Dinterman, and
D T George
May 1987,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
V B Solberg, and
F H Broski, and
R E Dinterman, and
D T George
August 2012,
Journal of controlled release : official journal of the Controlled Release Society,
V B Solberg, and
F H Broski, and
R E Dinterman, and
D T George
February 2013,
Toxicology in vitro : an international journal published in association with BIBRA,
V B Solberg, and
F H Broski, and
R E Dinterman, and
D T George
January 2009,
Toxicology,
V B Solberg, and
F H Broski, and
R E Dinterman, and
D T George
December 2011,
Nanotoxicology,
V B Solberg, and
F H Broski, and
R E Dinterman, and
D T George
March 1986,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
V B Solberg, and
F H Broski, and
R E Dinterman, and
D T George
September 1985,
Toxicology and applied pharmacology,
