BIOMAT Database Logo BIOMAT Database Logo

Peptidotriazoles with antimicrobial activity against bacterial and fungal plant pathogens. 2012

Imma Güell, and Lluís Micaló, and Laura Cano, and Esther Badosa, and Rafael Ferre, and Emilio Montesinos, and Eduard Bardají, and Lidia Feliu, and Marta Planas
LIPPSO, Department of Chemistry, University of Girona, Campus Montilivi, E-17071 Girona, Spain.

We designed and prepared peptidotriazoles based on the antimicrobial peptide BP100 (LysLysLeuPheLysLysIleLeuLysTyrLeu-NH(2)) by introducing a triazole ring in the peptide backbone or onto the side chain of a selected residue. These compounds were screened for their in vitro growth inhibition of bacterial and fungal phytopathogens, and for their cytotoxic effects on eukaryotic cells and tobacco leaves. Their proteolytic susceptibility was also analyzed. The antibacterial activity and the hemolysis were influenced by the amino acid that was modified with the triazole as well as by the absence of presence of a substituent in this heterocyclic ring. We identified sequences active against the bacteria Xanthomonas axonopodis pv. vesicatoria, Erwinia amylovora, Pseudomonas syringae pv. syringae (MIC of 1.6-12.5 μM), and against the fungi Fusarium oxysporum (MIC<6.2-12.5 μM) with low hemolytic activity (0-23% at 50 μM), high stability to protease digestion and no phytotoxicity. These peptidotriazoles constitute good candidates to design new antimicrobial agents.

UI MeSH Term Description Entries
D008826 Microbial Sensitivity Tests Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses). Bacterial Sensitivity Tests,Drug Sensitivity Assay, Microbial,Minimum Inhibitory Concentration,Antibacterial Susceptibility Breakpoint Determination,Antibiogram,Antimicrobial Susceptibility Breakpoint Determination,Bacterial Sensitivity Test,Breakpoint Determination, Antibacterial Susceptibility,Breakpoint Determination, Antimicrobial Susceptibility,Fungal Drug Sensitivity Tests,Fungus Drug Sensitivity Tests,Sensitivity Test, Bacterial,Sensitivity Tests, Bacterial,Test, Bacterial Sensitivity,Tests, Bacterial Sensitivity,Viral Drug Sensitivity Tests,Virus Drug Sensitivity Tests,Antibiograms,Concentration, Minimum Inhibitory,Concentrations, Minimum Inhibitory,Inhibitory Concentration, Minimum,Inhibitory Concentrations, Minimum,Microbial Sensitivity Test,Minimum Inhibitory Concentrations,Sensitivity Test, Microbial,Sensitivity Tests, Microbial,Test, Microbial Sensitivity,Tests, Microbial Sensitivity
D009842 Oligopeptides Peptides composed of between two and twelve amino acids. Oligopeptide
D004353 Drug Evaluation, Preclinical Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications. Drug Screening,Evaluation Studies, Drug, Pre-Clinical,Drug Evaluation Studies, Preclinical,Drug Evaluations, Preclinical,Evaluation Studies, Drug, Preclinical,Evaluation, Preclinical Drug,Evaluations, Preclinical Drug,Medicinal Plants Testing, Preclinical,Preclinical Drug Evaluation,Preclinical Drug Evaluations,Drug Screenings,Screening, Drug,Screenings, Drug
D005670 Fusarium A mitosporic Hypocreales fungal genus, various species of which are important parasitic pathogens of plants and a variety of vertebrates. Teleomorphs include GIBBERELLA. Fusariums
D000900 Anti-Bacterial Agents Substances that inhibit the growth or reproduction of BACTERIA. Anti-Bacterial Agent,Anti-Bacterial Compound,Anti-Mycobacterial Agent,Antibacterial Agent,Antibiotics,Antimycobacterial Agent,Bacteriocidal Agent,Bacteriocide,Anti-Bacterial Compounds,Anti-Mycobacterial Agents,Antibacterial Agents,Antibiotic,Antimycobacterial Agents,Bacteriocidal Agents,Bacteriocides,Agent, Anti-Bacterial,Agent, Anti-Mycobacterial,Agent, Antibacterial,Agent, Antimycobacterial,Agent, Bacteriocidal,Agents, Anti-Bacterial,Agents, Anti-Mycobacterial,Agents, Antibacterial,Agents, Antimycobacterial,Agents, Bacteriocidal,Anti Bacterial Agent,Anti Bacterial Agents,Anti Bacterial Compound,Anti Bacterial Compounds,Anti Mycobacterial Agent,Anti Mycobacterial Agents,Compound, Anti-Bacterial,Compounds, Anti-Bacterial
D000935 Antifungal Agents Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. Anti-Fungal Agents,Antifungal Agent,Fungicides, Therapeutic,Antibiotics, Antifungal,Therapeutic Fungicides,Agent, Antifungal,Anti Fungal Agents,Antifungal Antibiotics
D014230 Triazoles Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3. Triazole
D015195 Drug Design The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include PHARMACOKINETICS, dosage analysis, or drug administration analysis. Computer-Aided Drug Design,Computerized Drug Design,Drug Modeling,Pharmaceutical Design,Computer Aided Drug Design,Computer-Aided Drug Designs,Computerized Drug Designs,Design, Pharmaceutical,Drug Design, Computer-Aided,Drug Design, Computerized,Drug Designs,Drug Modelings,Pharmaceutical Designs
D044084 Erwinia amylovora A species of gram-negative bacteria, in the genus ERWINIA, causing a necrotic disease of plants. Bacillus amylovorus,Bacterium amylovorus,Micrococcus amylovorus
D044224 Pseudomonas syringae A species of gram-negative, fluorescent, phytopathogenic bacteria in the genus PSEUDOMONAS. It is differentiated into approximately 50 pathovars with different plant pathogenicities and host specificities. Pseudomonas syringae subsp. syringae

Related Publications

Imma Güell, and Lluís Micaló, and Laura Cano, and Esther Badosa, and Rafael Ferre, and Emilio Montesinos, and Eduard Bardají, and Lidia Feliu, and Marta Planas
Antimicrobial activity of nicotine against a spectrum of bacterial and fungal pathogens.
July 2000, Journal of medical microbiology,
Imma Güell, and Lluís Micaló, and Laura Cano, and Esther Badosa, and Rafael Ferre, and Emilio Montesinos, and Eduard Bardají, and Lidia Feliu, and Marta Planas
Antimicrobial Peptides Demonstrate Activity against Resistant Bacterial Pathogens.
August 2023, Infectious disease reports,
Imma Güell, and Lluís Micaló, and Laura Cano, and Esther Badosa, and Rafael Ferre, and Emilio Montesinos, and Eduard Bardají, and Lidia Feliu, and Marta Planas
Antibacterial Surfaces with Activity against Antimicrobial Resistant Bacterial Pathogens and Endospores.
May 2020, ACS infectious diseases,
Imma Güell, and Lluís Micaló, and Laura Cano, and Esther Badosa, and Rafael Ferre, and Emilio Montesinos, and Eduard Bardají, and Lidia Feliu, and Marta Planas
Activity of N-Phenylpiperazine Derivatives Against Bacterial and Fungal Pathogens.
January 2019, Current protein & peptide science,
Imma Güell, and Lluís Micaló, and Laura Cano, and Esther Badosa, and Rafael Ferre, and Emilio Montesinos, and Eduard Bardají, and Lidia Feliu, and Marta Planas
Douglas-fir root-associated microorganisms with inhibitory activity towards fungal plant pathogens and human bacterial pathogens.
July 1996, Canadian journal of microbiology,
Imma Güell, and Lluís Micaló, and Laura Cano, and Esther Badosa, and Rafael Ferre, and Emilio Montesinos, and Eduard Bardají, and Lidia Feliu, and Marta Planas
Antimicrobial activity of plant extracts against sexually transmitted pathogens.
January 2015, Natural product research,
Imma Güell, and Lluís Micaló, and Laura Cano, and Esther Badosa, and Rafael Ferre, and Emilio Montesinos, and Eduard Bardají, and Lidia Feliu, and Marta Planas
Antimicrobial activity of simulated solar disinfection against bacterial, fungal, and protozoan pathogens and its enhancement by riboflavin.
September 2010, Applied and environmental microbiology,
Imma Güell, and Lluís Micaló, and Laura Cano, and Esther Badosa, and Rafael Ferre, and Emilio Montesinos, and Eduard Bardají, and Lidia Feliu, and Marta Planas
Semisynthetic Macrocyclic Lipo-lanthipeptides Display Antimicrobial Activity Against Bacterial Pathogens.
August 2021, ACS synthetic biology,
Imma Güell, and Lluís Micaló, and Laura Cano, and Esther Badosa, and Rafael Ferre, and Emilio Montesinos, and Eduard Bardají, and Lidia Feliu, and Marta Planas
Synthesis and antifungal activity of 2-allylphenol derivatives against fungal plant pathogens.
January 2017, Pesticide biochemistry and physiology,
Imma Güell, and Lluís Micaló, and Laura Cano, and Esther Badosa, and Rafael Ferre, and Emilio Montesinos, and Eduard Bardají, and Lidia Feliu, and Marta Planas
Synthetic ultrashort cationic lipopeptides induce systemic plant defense responses against bacterial and fungal pathogens.
August 2009, Applied and environmental microbiology,
Copied contents to your clipboard!