BIOMAT Database Logo BIOMAT Database Logo

Gating and permeation of Orai channels. 2012

Isabella Derler, and Rainer Schindl, and Reinhard Fritsch, and Christoph Romanin
Institute of Biophysics, University of Linz, A-4040 Linz, Austria. isabella.derler@jku.at

Ca2+ release-activated Ca2+ channels mediate a sustained Ca2+ influx following depletion of endoplasmic reticulum stores. This signalling cascade that triggers T-cell activation or mast cell degranulation involves STIM1, the Ca2+ sensor in the endoplasmic reticulum, and the Ca2+ selective Orai channel in the plasma membrane. This review describes the molecular mechanism (s) governing the STIM1/Orai signalling machinery. Moreover, we provide an overview on additional proteins modulating or interacting with the STIM1/Orai1 system. A structure-function relationship highlights regions within STIM1/Orai proteins contributing to activation, permeation and inactivation of CRAC currents.

UI MeSH Term Description Entries
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D015398 Signal Transduction The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway. Cell Signaling,Receptor-Mediated Signal Transduction,Signal Pathways,Receptor Mediated Signal Transduction,Signal Transduction Pathways,Signal Transduction Systems,Pathway, Signal,Pathway, Signal Transduction,Pathways, Signal,Pathways, Signal Transduction,Receptor-Mediated Signal Transductions,Signal Pathway,Signal Transduction Pathway,Signal Transduction System,Signal Transduction, Receptor-Mediated,Signal Transductions,Signal Transductions, Receptor-Mediated,System, Signal Transduction,Systems, Signal Transduction,Transduction, Signal,Transductions, Signal
D015640 Ion Channel Gating The opening and closing of ion channels due to a stimulus. The stimulus can be a change in membrane potential (voltage-gated), drugs or chemical transmitters (ligand-gated), or a mechanical deformation. Gating is thought to involve conformational changes of the ion channel which alters selective permeability. Gating, Ion Channel,Gatings, Ion Channel,Ion Channel Gatings

Related Publications

Isabella Derler, and Rainer Schindl, and Reinhard Fritsch, and Christoph Romanin
Interrogating permeation and gating of Orai channels using chemical modification of cysteine residues.
January 2021, Methods in enzymology,
Isabella Derler, and Rainer Schindl, and Reinhard Fritsch, and Christoph Romanin
Structural Insights into Ca2+ Permeation through Orai Channels.
November 2021, Cells,
Isabella Derler, and Rainer Schindl, and Reinhard Fritsch, and Christoph Romanin
Gating and permeation models of plant channels.
March 1997, Journal of experimental botany,
Isabella Derler, and Rainer Schindl, and Reinhard Fritsch, and Christoph Romanin
Gating and permeation of different types of Ca channels.
January 1989, Annals of the New York Academy of Sciences,
Isabella Derler, and Rainer Schindl, and Reinhard Fritsch, and Christoph Romanin
Molecular determinants of fast Ca2+-dependent inactivation and gating of the Orai channels.
August 2009, Proceedings of the National Academy of Sciences of the United States of America,
Isabella Derler, and Rainer Schindl, and Reinhard Fritsch, and Christoph Romanin
Permeation and gating mechanisms in store-operated CRAC channels.
January 2012, Frontiers in bioscience (Landmark edition),
Isabella Derler, and Rainer Schindl, and Reinhard Fritsch, and Christoph Romanin
Permeation, selectivity and gating in store-operated CRAC channels.
September 2012, The Journal of physiology,
Isabella Derler, and Rainer Schindl, and Reinhard Fritsch, and Christoph Romanin
Gating movements and ion permeation in HCN4 pacemaker channels.
July 2021, Molecular cell,
Isabella Derler, and Rainer Schindl, and Reinhard Fritsch, and Christoph Romanin
Coupling gating with ion permeation in ClC channels.
June 2003, Science's STKE : signal transduction knowledge environment,
Isabella Derler, and Rainer Schindl, and Reinhard Fritsch, and Christoph Romanin
Aromatic residues affecting permeation and gating in dSlo BK channels.
April 1998, Pflugers Archiv : European journal of physiology,
Copied contents to your clipboard!