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This study investigated the protective effects of melatonin (MLT) against doxorubicin (DXR)-induced testicular toxicity and oxidative stress in rats. DXR was given as a single intraperitoneal dose of 10 mg kg(-1) body weight to male rats at 1 h after MLT treatment on day 6 of the study. MLT at 15 mg kg(-1) body weight was administered daily by gavage for 5 days before DXR treatment followed by an additional dose for 5 days. Sperm analysis, histopathological examination and biochemical methods were used for this investigation. DXR caused a decrease in the weight of seminal vesicles, epididymal sperm count and motility and an increase in the incidence of histopathological changes of the testis. In addition, an increased malondialdehyde (MDA) concentration and decreased glutathione content, glutathione reductase (GR), glutathione-S-transferase (GST), superoxide dismutase (SOD) and catalase activities were observed. On the contrary, MLT treatment significantly ameliorated DXR-induced testicular toxicity in rats. Moreover, MDA concentration and GR, GST and SOD activities were not affected when MLT was administered in conjunction with DXR. These results indicate that MLT had a protective effect against DXR-induced testicular toxicity and that the protective effects of MLT may be due to both the inhibition of lipid peroxidation and increased antioxidant activity.
K-M Lee, and
I-C Lee, and
S-H Kim, and
C Moon, and
S-H Park, and
D-H Shin, and
S-H Kim, and
S-C Park, and
H-C Kim, and
J-C Kim
May 2014,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
K-M Lee, and
I-C Lee, and
S-H Kim, and
C Moon, and
S-H Park, and
D-H Shin, and
S-H Kim, and
S-C Park, and
H-C Kim, and
J-C Kim
February 2009,
Toxicology,
K-M Lee, and
I-C Lee, and
S-H Kim, and
C Moon, and
S-H Park, and
D-H Shin, and
S-H Kim, and
S-C Park, and
H-C Kim, and
J-C Kim
October 2020,
Andrologia,
K-M Lee, and
I-C Lee, and
S-H Kim, and
C Moon, and
S-H Park, and
D-H Shin, and
S-H Kim, and
S-C Park, and
H-C Kim, and
J-C Kim
January 2022,
Journal of human reproductive sciences,
K-M Lee, and
I-C Lee, and
S-H Kim, and
C Moon, and
S-H Park, and
D-H Shin, and
S-H Kim, and
S-C Park, and
H-C Kim, and
J-C Kim
August 2006,
Journal of pineal research,
K-M Lee, and
I-C Lee, and
S-H Kim, and
C Moon, and
S-H Park, and
D-H Shin, and
S-H Kim, and
S-C Park, and
H-C Kim, and
J-C Kim
October 2015,
Reproduction (Cambridge, England),
K-M Lee, and
I-C Lee, and
S-H Kim, and
C Moon, and
S-H Park, and
D-H Shin, and
S-H Kim, and
S-C Park, and
H-C Kim, and
J-C Kim
December 2014,
Systems biology in reproductive medicine,
K-M Lee, and
I-C Lee, and
S-H Kim, and
C Moon, and
S-H Park, and
D-H Shin, and
S-H Kim, and
S-C Park, and
H-C Kim, and
J-C Kim
March 2016,
Human & experimental toxicology,
K-M Lee, and
I-C Lee, and
S-H Kim, and
C Moon, and
S-H Park, and
D-H Shin, and
S-H Kim, and
S-C Park, and
H-C Kim, and
J-C Kim
May 2012,
Phytotherapy research : PTR,
K-M Lee, and
I-C Lee, and
S-H Kim, and
C Moon, and
S-H Park, and
D-H Shin, and
S-H Kim, and
S-C Park, and
H-C Kim, and
J-C Kim
August 2016,
Cardiovascular therapeutics,
