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Paraneoplastic encephalitis associated with myasthenia gravis and malignant thymoma. 2012
Yu Miyazaki, and
Masaaki Hirayama, and
Hirohisa Watanabe, and
Noriyasu Usami, and
Kohei Yokoi, and
Osamu Watanabe, and
Gen Sobue
Department of Neurology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.
We present a patient with type B2 thymoma (World Health Organization Thymoma Classification) with the complications of anti-muscle acetylcholine receptor antibody-positive myasthenia gravis and anti-voltage-gated potassium channel antibodies associated with paraneoplastic encephalitis. A timing difference between the onset of these neurological disorders and a dissociation of clinical symptoms was observed during the disease. This report alerts clinicians that long-term follow-up is needed where patients have a residual thymoma and attention should be paid to other concomitant autoimmune disorders.
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