BIOMAT Database Logo BIOMAT Database Logo

Plasma beta-endorphin levels in chronic alcoholics. 1990

J C Aguirre, and J L Del Arbol, and J Raya, and M E Ruiz-Requena, and J Rico Irles
Department of Medicine, Hospital Universitario San Cecilio, Facultad de Medicina, Granada, Spain.

In order to test the possible relationship between the chronic consumption of alcohol and the opioid system, we have measured the plasma levels of beta-endorphin in a group of 31 alcoholic patients and compared the results with those of a control group of 16 subjects. Our results show that chronic consumption of alcohol induces a significant decrease in beta-endorphin (beta-end) plasma levels regardless of either the disease suffered by the alcoholic patient or of the time of abstinence studied (one month maximum). Thus we believe that the beta-end decrease may well be due to the patients' alcoholism and that it might be mediated by the tetrahydroisoquinoline system, or be a cause of alcoholism rather than a consequence.

UI MeSH Term Description Entries
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000437 Alcoholism A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4) Alcohol Abuse,Alcoholic Intoxication, Chronic,Ethanol Abuse,Alcohol Addiction,Alcohol Dependence,Alcohol Use Disorder,Abuse, Alcohol,Abuse, Ethanol,Addiction, Alcohol,Alcohol Use Disorders,Chronic Alcoholic Intoxication,Dependence, Alcohol,Intoxication, Chronic Alcoholic,Use Disorders, Alcohol
D001615 beta-Endorphin A 31-amino acid peptide that is the C-terminal fragment of BETA-LIPOTROPIN. It acts on OPIOID RECEPTORS and is an analgesic. Its first four amino acids at the N-terminal are identical to the tetrapeptide sequence of METHIONINE ENKEPHALIN and LEUCINE ENKEPHALIN. Endorphin, beta,beta-Endorphin (1-31),beta Endorphin
D013312 Stress, Physiological The unfavorable effect of environmental factors (stressors) on the physiological functions of an organism. Prolonged unresolved physiological stress can affect HOMEOSTASIS of the organism, and may lead to damaging or pathological conditions. Biotic Stress,Metabolic Stress,Physiological Stress,Abiotic Stress,Abiotic Stress Reaction,Abiotic Stress Response,Biological Stress,Metabolic Stress Response,Physiological Stress Reaction,Physiological Stress Reactivity,Physiological Stress Response,Abiotic Stress Reactions,Abiotic Stress Responses,Abiotic Stresses,Biological Stresses,Biotic Stresses,Metabolic Stress Responses,Metabolic Stresses,Physiological Stress Reactions,Physiological Stress Responses,Physiological Stresses,Reaction, Abiotic Stress,Reactions, Abiotic Stress,Response, Abiotic Stress,Response, Metabolic Stress,Stress Reaction, Physiological,Stress Response, Metabolic,Stress Response, Physiological,Stress, Abiotic,Stress, Biological,Stress, Biotic,Stress, Metabolic

Related Publications

J C Aguirre, and J L Del Arbol, and J Raya, and M E Ruiz-Requena, and J Rico Irles
Plasma beta-endorphin, but not met-enkephalin levels are abnormal in chronic alcoholics.
September 1992, Alcohol and alcoholism (Oxford, Oxfordshire),
J C Aguirre, and J L Del Arbol, and J Raya, and M E Ruiz-Requena, and J Rico Irles
Plasma beta-endorphin levels in chronic schizophrenic patients normal controls.
November 1979, Artificial organs,
J C Aguirre, and J L Del Arbol, and J Raya, and M E Ruiz-Requena, and J Rico Irles
[Plasma beta-endorphin levels in depressive patients under chronic hemodialysis].
January 1984, Harefuah,
J C Aguirre, and J L Del Arbol, and J Raya, and M E Ruiz-Requena, and J Rico Irles
Plasma norharman (beta-carboline) levels are elevated in chronic alcoholics.
June 1991, Alcoholism, clinical and experimental research,
J C Aguirre, and J L Del Arbol, and J Raya, and M E Ruiz-Requena, and J Rico Irles
Alpha-theta brainwave training and beta-endorphin levels in alcoholics.
April 1989, Alcoholism, clinical and experimental research,
J C Aguirre, and J L Del Arbol, and J Raya, and M E Ruiz-Requena, and J Rico Irles
Abnormal plasma oxytocin and beta-endorphin levels in alcoholics after short and long term abstinence.
July 1997, Progress in neuro-psychopharmacology & biological psychiatry,
J C Aguirre, and J L Del Arbol, and J Raya, and M E Ruiz-Requena, and J Rico Irles
Beta-endorphin, beta-lipotropin and adrenocorticotropic hormone levels in cerebrospinal fluid, and brain damage in chronic alcoholics.
January 1983, European neurology,
J C Aguirre, and J L Del Arbol, and J Raya, and M E Ruiz-Requena, and J Rico Irles
Plasma beta-endorphin levels during obstetrical analgesia with synthetic beta-endorphin.
February 1986, Agressologie: revue internationale de physio-biologie et de pharmacologie appliquees aux effets de l'agression,
J C Aguirre, and J L Del Arbol, and J Raya, and M E Ruiz-Requena, and J Rico Irles
Plasma beta-endorphin levels after exercise.
February 1985, Journal of endocrinological investigation,
J C Aguirre, and J L Del Arbol, and J Raya, and M E Ruiz-Requena, and J Rico Irles
Plasma beta-endorphin levels in primary aldosteronism.
February 1985, The Journal of clinical endocrinology and metabolism,
Copied contents to your clipboard!