-transparent.png){kind=logo}
This study was designed to evaluate the contribution of calmodulin and protein kinase C to renin release from isolated glomeruli of spontaneously hypertensive rats (SHR, Okamoto and Aoki). Male 7-week-old SHR and age-matched control Wistar-Kyoto rats (WKY) were used in this study. Isolated glomeruli were sealed in the superfusion chamber and perfused with Krebs-Ringer solution at a constant flow of 0.3 mL/min. Renin release was increased by calmodulin inhibitor, W-7, and protein kinase C inhibitor, H-7, in both SHR and WKY. SHR showed higher maximal levels of renin release by W-7 and lower maximal levels by H-7 compared to WKY. These results indicate that calmodulin and protein kinase C play inhibitory roles in renin release from juxtaglomerular cells. The calmodulin-mediated suppression mechanism in renin release appears to be augmented in the SHR, whereas the protein kinase C-mediated system is attenuated.
T Hano, and
M Shiotani, and
A Baba, and
M Ura, and
Y Nakamura, and
Y Tomobuchi, and
I Nishio, and
Y Masuyama
December 1988,
Journal of hypertension. Supplement : official journal of the International Society of Hypertension,
T Hano, and
M Shiotani, and
A Baba, and
M Ura, and
Y Nakamura, and
Y Tomobuchi, and
I Nishio, and
Y Masuyama
January 1992,
Clinical and experimental hypertension. Part A, Theory and practice,
T Hano, and
M Shiotani, and
A Baba, and
M Ura, and
Y Nakamura, and
Y Tomobuchi, and
I Nishio, and
Y Masuyama
November 1990,
American journal of hypertension,
T Hano, and
M Shiotani, and
A Baba, and
M Ura, and
Y Nakamura, and
Y Tomobuchi, and
I Nishio, and
Y Masuyama
March 1992,
European journal of pharmacology,
T Hano, and
M Shiotani, and
A Baba, and
M Ura, and
Y Nakamura, and
Y Tomobuchi, and
I Nishio, and
Y Masuyama
December 1988,
Journal of hypertension. Supplement : official journal of the International Society of Hypertension,
T Hano, and
M Shiotani, and
A Baba, and
M Ura, and
Y Nakamura, and
Y Tomobuchi, and
I Nishio, and
Y Masuyama
December 1998,
Hypertension (Dallas, Tex. : 1979),
T Hano, and
M Shiotani, and
A Baba, and
M Ura, and
Y Nakamura, and
Y Tomobuchi, and
I Nishio, and
Y Masuyama
July 1989,
Biulleten' eksperimental'noi biologii i meditsiny,
T Hano, and
M Shiotani, and
A Baba, and
M Ura, and
Y Nakamura, and
Y Tomobuchi, and
I Nishio, and
Y Masuyama
November 1992,
European journal of pharmacology,
T Hano, and
M Shiotani, and
A Baba, and
M Ura, and
Y Nakamura, and
Y Tomobuchi, and
I Nishio, and
Y Masuyama
August 1966,
Saishin igaku. Modern medicine,
T Hano, and
M Shiotani, and
A Baba, and
M Ura, and
Y Nakamura, and
Y Tomobuchi, and
I Nishio, and
Y Masuyama
January 1984,
Contributions to nephrology,
