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Bakuchiol derivatives as novel and potent cytotoxic agents: a report. 2012
Rabiya Majeed, and
Mallepally V Reddy, and
Praveen K Chinthakindi, and
Payare L Sangwan, and
Abid Hamid, and
Gousia Chashoo, and
Ajit K Saxena, and
Surrinder Koul
Bioorganic Chemistry Section, CSIR-Indian Institute of Integrative Medicine, Jammu, India.
A library of 28 compounds comprising of acyl, amino, halo, nitro, styryl and cyclized derivatives of bakuchiol have been evaluated against a panel of eight human cancer cell lines. Bioevaluation studies have resulted in the identification of potent cytotoxic molecules exhibiting concentration dependent growth inhibition against leukemia cancer cells with best results observed for compounds 17 and 22 exhibiting IC(50) 1.8 and 2.0 μM respectively. As evident from various biological end-points, inhibition of cell proliferation by inducing G2/M cell cycle arrest, mitochondrial membrane disruption followed by DNA fragmentation and apoptosis is demonstrated.
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