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Sodium nitroprusside effected a significant reduction in intracellular cAMP accumulation and parathyroid hormone release in dispersed bovine parathyroid cells. The inhibition was apparent at 3 x 10-4 M and maximal at 10-2 M nitroprusside. The effect was rapid and reversible and could be demonstrated in both the presence and absence of stimulating agonists [i.e. (-)isoproterenol, dopamine, and cholera toxin]. The inhibition was additive with that previously described for alpha-adrenergic agonists and prostaglandin F2 alpha and was not affected by phentolamine, suggesting that nitroprusside does not act through the inhibitory receptors previously described in this system. The nitroprusside effect on cAMP accumulation and parathyroid hormone release was present at virtually all concentrations of extracellular calcium tested; 2mM EGTA failed to prevent the inhibition. While extracellular calcium may play some role in this inhibition, it is not required for demonstration of the effect.
D G Gardner, and
E M Brown, and
G D Aurbach
September 1978,
Endocrinology,
D G Gardner, and
E M Brown, and
G D Aurbach
May 1981,
The Journal of clinical endocrinology and metabolism,
D G Gardner, and
E M Brown, and
G D Aurbach
February 1974,
Biochemical and biophysical research communications,
D G Gardner, and
E M Brown, and
G D Aurbach
March 1973,
Endocrinology,
D G Gardner, and
E M Brown, and
G D Aurbach
July 1983,
Endocrinology,
D G Gardner, and
E M Brown, and
G D Aurbach
December 1980,
The Journal of clinical endocrinology and metabolism,
D G Gardner, and
E M Brown, and
G D Aurbach
February 1973,
California medicine,
D G Gardner, and
E M Brown, and
G D Aurbach
April 1970,
Endocrinology,
D G Gardner, and
E M Brown, and
G D Aurbach
January 1984,
The Journal of clinical endocrinology and metabolism,
D G Gardner, and
E M Brown, and
G D Aurbach
July 1979,
Endocrinology,
