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Synthetic sialyl glycolipids (sialo-cholesterol and sialo-diglyceride) induce granulocytic differentiation of human myelogenous leukemia cell line HL-60. 1990
M Saito, and
H Nojiri, and
H Ogino, and
A Yuo, and
H Ogura, and
M Itoh, and
K Tomita, and
T Ogawa, and
Y Nagai, and
S Kitagawa
Division of Hemopoiesis, Jichi Medical School, Tochigi, Japan.
When HL-60 cells were cultivated with synthetic sialyl glycolipids, sialo-cholesterol and sialo-diglyceride, the cells were found to be differentiated into mature granulocytes on morphological and functional criteria. The differentiation of cells was accompanied by inhibition of cell proliferation. The differentiation-inducing activity of sialo-cholesterol was greater than that of sialo-diglyceride on a molar basis, and the alpha-anomer of each compound was more potent than the beta-anomer, suggesting that the stereospecific structure of the compounds is important for the differentiation-inducing activity.
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