BIOMAT Database Logo BIOMAT Database Logo

Long-term outcome after surgery for biliary atresia. Study of 40 patients surviving for more than 10 years. 1990

J Laurent, and F Gauthier, and O Bernard, and M Hadchouel, and M Odièvre, and J Valayer, and D Alagille
Unité de Recherches d'Hépatologie Pédiatrique, INSERM U 56, Kremlin-Bicêtre, France.

To define long-term prognosis of children who underwent surgery for biliary atresia, a retrospective study was undertaken in 122 children who underwent one of the Kasaï procedures between 1968 and 1977. Forty of the 122 children (32.7%) were alive after 10 years. Firm hepatomegaly was present in 31 and splenomegaly in 29 children. Serum bilirubin or all liver function tests were normal in 21 and 11 children, respectively; survival rate decreased with the age at operation, but no significant difference was observed in the rate of children surviving with normal serum bilirubin whether they underwent surgery before age 2 months or between 2 and 3 months. Twenty-four had esophageal varices and 15 experienced gastrointestinal bleeding. Normal liver-function tests and absence of portal hypertension were observed in 11 of 122 children. These results indicate that Kasaï's procedures were helpful in a significant proportion of children with biliary atresia who underwent surgery during this period. However, 80% of children who initially underwent surgery with Kasaï's procedures should eventually undergo liver transplantation.

UI MeSH Term Description Entries
D006975 Hypertension, Portal Abnormal increase of resistance to blood flow within the hepatic PORTAL SYSTEM, frequently seen in LIVER CIRRHOSIS and conditions with obstruction of the PORTAL VEIN. Cruveilhier-Baumgarten Disease,Cruveilhier-Baumgarten Syndrome,Cruveilhier Baumgarten Disease,Cruveilhier Baumgarten Syndrome,Disease, Cruveilhier-Baumgarten,Portal Hypertension,Portal Hypertensions,Syndrome, Cruveilhier-Baumgarten
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D011184 Postoperative Period The period following a surgical operation. Period, Postoperative,Periods, Postoperative,Postoperative Periods
D002423 Cause of Death Factors which produce cessation of all vital bodily functions. They can be analyzed from an epidemiologic viewpoint. Causes of Death,Death Cause,Death Causes
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D002761 Cholangitis Inflammation of the biliary ductal system (BILE DUCTS); intrahepatic, extrahepatic, or both. Cholangitides
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D001656 Biliary Atresia Progressive destruction or the absence of all or part of the extrahepatic BILE DUCTS, resulting in the complete obstruction of BILE flow. Usually, biliary atresia is found in infants and accounts for one third of the neonatal cholestatic JAUNDICE. Atresia, Biliary,Biliary Atresia, Extrahepatic,Biliary Atresia, Intrahepatic,Extrahepatic Biliary Atresia,Familial Extrahepatic Biliary Atresia,Idiopathic Extrahepatic Biliary Atresia,Intrahepatic Biliary Atresia,Atresia, Extrahepatic Biliary,Atresia, Intrahepatic Biliary

Related Publications

J Laurent, and F Gauthier, and O Bernard, and M Hadchouel, and M Odièvre, and J Valayer, and D Alagille
Outcome of 21 patients with biliary atresia living more than 10 years.
November 1993, Journal of pediatric surgery,
J Laurent, and F Gauthier, and O Bernard, and M Hadchouel, and M Odièvre, and J Valayer, and D Alagille
Long-term complications in patients surviving more than 10 years on hemodialysis.
December 1999, Transplantation proceedings,
J Laurent, and F Gauthier, and O Bernard, and M Hadchouel, and M Odièvre, and J Valayer, and D Alagille
Long-term outcome of patients surviving for more than ten years following treatment for acute leukaemia.
May 2001, British journal of haematology,
J Laurent, and F Gauthier, and O Bernard, and M Hadchouel, and M Odièvre, and J Valayer, and D Alagille
[Long-term outcome of surgery for biliary atresia].
August 1996, Nihon Geka Gakkai zasshi,
J Laurent, and F Gauthier, and O Bernard, and M Hadchouel, and M Odièvre, and J Valayer, and D Alagille
Clinical study of patients with renal carcinoma surviving for more than 10 years after nephrectomy.
November 1992, British journal of urology,
J Laurent, and F Gauthier, and O Bernard, and M Hadchouel, and M Odièvre, and J Valayer, and D Alagille
Isolated arthroscopic meniscal repair: a long-term outcome study (more than 10 years).
January 1999, The American journal of sports medicine,
J Laurent, and F Gauthier, and O Bernard, and M Hadchouel, and M Odièvre, and J Valayer, and D Alagille
Long-term use of ciclosporin on kidney transplant recipients surviving more than 10 years.
July 2014, Die Pharmazie,
J Laurent, and F Gauthier, and O Bernard, and M Hadchouel, and M Odièvre, and J Valayer, and D Alagille
Prostate cancer mortality in patients surviving more than 10 years after diagnosis.
December 1995, The Journal of urology,
J Laurent, and F Gauthier, and O Bernard, and M Hadchouel, and M Odièvre, and J Valayer, and D Alagille
Long-term follow-up after surgery for patients with biliary atresia.
April 1990, Journal of pediatric surgery,
J Laurent, and F Gauthier, and O Bernard, and M Hadchouel, and M Odièvre, and J Valayer, and D Alagille
Re: Prostate cancer mortality in patients surviving more than 10 years after diagnosis.
November 1996, The Journal of urology,
Copied contents to your clipboard!