Biomaterial Database

Statistical aspects of experimental studies with complex mixtures. 1990

J Wahrendorf

Institute of Epidemiology and Biometry, German Cancer Research Centre, Heidelberg.

Some formal concepts are introduced relating to the statistical design and analysis of experiments with complex mixtures. Aspects relating to the chemical analysis of complex mixtures, identification of their major components, continuous monitoring of samples or related issues are not addressed. As a surrogate for experimental studies in general, the discussion is oriented towards the situation of long-term animal experiments. When complex mixtures of unknown components are to be tested, samples collected under a standardized protocol must be applied to the different exposure groups in such a way that the experimental groups differ only in the dose of the exposure they receive. If the composition of a mixture is known, selected components may be combined in experimental testing in order to study the nature of their joint effect. Careful consideration guided by a priori knowledge about the individual compounds' dose-response relationships is required to design and analyse such experiments. There is an apparent need to avoid confusion by unifying the terminology in this field.

UI	MeSH Term	Description	Entries
D008452	Maximum Allowable Concentration	The maximum exposure to a biologically active physical or chemical agent that is allowed during an 8-hour period (a workday) in a population of workers, or during a 24-hour period in the general population, which does not appear to cause appreciable harm, whether immediate or delayed for any period, in the target population. (From Lewis Dictionary of Toxicology, 1st ed)	Maximum Permissible Exposure Level,MPEL,Maximum Permissible Exposure Concentration,Allowable Concentration, Maximum,Allowable Concentrations, Maximum,Concentration, Maximum Allowable,Concentrations, Maximum Allowable,MPELs,Maximum Allowable Concentrations
D002274	Carcinogens, Environmental	Carcinogenic substances that are found in the environment.	Environmental Carcinogens
D004357	Drug Synergism	The action of a drug in promoting or enhancing the effectiveness of another drug.	Drug Potentiation,Drug Augmentation,Augmentation, Drug,Augmentations, Drug,Drug Augmentations,Drug Potentiations,Drug Synergisms,Potentiation, Drug,Potentiations, Drug,Synergism, Drug,Synergisms, Drug
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D015233	Models, Statistical	Statistical formulations or analyses which, when applied to data and found to fit the data, are then used to verify the assumptions and parameters used in the analysis. Examples of statistical models are the linear model, binomial model, polynomial model, two-parameter model, etc.	Probabilistic Models,Statistical Models,Two-Parameter Models,Model, Statistical,Models, Binomial,Models, Polynomial,Statistical Model,Binomial Model,Binomial Models,Model, Binomial,Model, Polynomial,Model, Probabilistic,Model, Two-Parameter,Models, Probabilistic,Models, Two-Parameter,Polynomial Model,Polynomial Models,Probabilistic Model,Two Parameter Models,Two-Parameter Model