-transparent.png){kind=logo}
Human lung and bladder DNA has been isolated and purified from either surgical or autopsy specimens. Smoking history details were obtained from patients or their close relatives. Each DNA sample was investigated using the nuclease P1 digestion modification of the 32P-postlabelling procedure. Data are presented for 48 lung and 19 bladder specimens. The samples were subdivided into three groups for data analysis, viz. smokers, former smokers and nonsmokers. The mean adduct levels (adducts per 10(8) nucleotides) in lung samples were: [see text] The chromatographic pattern of bladder DNA adducts for smokers was similar to that for smokers' lung DNA, although less intense. Adduct levels in former smokers tended to be lower than in smokers, although loss of adducts appeared to require several years after cessation of smoking. These findings support a link between DNA adduct levels and cigarette smoking, for both the lung and the bladder. For the former tissue there was a strong linear correlation between adduct levels and the number of cigarettes smoked.
R C Garner, and
J Cuzick, and
D Jenkins, and
D H Phillips, and
A Hewer, and
M M King, and
M N Routledge
May 1998,
Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine],
R C Garner, and
J Cuzick, and
D Jenkins, and
D H Phillips, and
A Hewer, and
M M King, and
M N Routledge
August 1990,
British journal of cancer,
R C Garner, and
J Cuzick, and
D Jenkins, and
D H Phillips, and
A Hewer, and
M M King, and
M N Routledge
January 1964,
The British journal of medical psychology,
R C Garner, and
J Cuzick, and
D Jenkins, and
D H Phillips, and
A Hewer, and
M M King, and
M N Routledge
December 2009,
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology,
R C Garner, and
J Cuzick, and
D Jenkins, and
D H Phillips, and
A Hewer, and
M M King, and
M N Routledge
March 1991,
Cancer causes & control : CCC,
R C Garner, and
J Cuzick, and
D Jenkins, and
D H Phillips, and
A Hewer, and
M M King, and
M N Routledge
March 1973,
Thorax,
R C Garner, and
J Cuzick, and
D Jenkins, and
D H Phillips, and
A Hewer, and
M M King, and
M N Routledge
April 2009,
Environmental health perspectives,
R C Garner, and
J Cuzick, and
D Jenkins, and
D H Phillips, and
A Hewer, and
M M King, and
M N Routledge
March 2004,
Journal of endocrinological investigation,
R C Garner, and
J Cuzick, and
D Jenkins, and
D H Phillips, and
A Hewer, and
M M King, and
M N Routledge
June 1993,
Journal of UOEH,
R C Garner, and
J Cuzick, and
D Jenkins, and
D H Phillips, and
A Hewer, and
M M King, and
M N Routledge
January 1988,
Nature,
