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The relationship of the intensity of occupational vapor exposure to isopropyl alcohol (IPA) with urinary excretion of acetone and unmetabolized IPA was studied in 99 printers of both sexes, who were exposed to up to 66 ppm IPA (as time-weighted average), together with toluene, xylenes, methyl ethyl ketone and/or ethyl acetate. Acetone and IPA concentrations in urine were studied also in 34 non-exposed subjects. Acetone was detectable in the urine of most of the non-exposed, and the urinary acetone concentration increased in proportion to the IPA exposure intensity (r = 0.84 for observed, non-corrected values), whereas the correction for creatinine concentration or specific gravity of urine did not give a larger correlation coefficient. IPA itself was not found in the urine of the non-exposed, and was detectable in urine of only those who were exposed to IPA above a certain level, e.g. 5 ppm. The present study results suggest that urinary acetone is a valuable index for biological monitoring of occupational exposure to IPA as low as 70 ppm.
T Kawai, and
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January 1996,
Industrial health,
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O Iwami, and
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T Watanabe, and
H Nakatsuka, and
M Ikeda
September 1998,
International archives of occupational and environmental health,
T Kawai, and
T Yasugi, and
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T Watanabe, and
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M Ikeda
January 2015,
Journal of occupational health,
T Kawai, and
T Yasugi, and
S Horiguchi, and
Y Uchida, and
O Iwami, and
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T Watanabe, and
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M Ikeda
February 2020,
Industrial health,
T Kawai, and
T Yasugi, and
S Horiguchi, and
Y Uchida, and
O Iwami, and
H Iguchi, and
O Inoue, and
T Watanabe, and
H Nakatsuka, and
M Ikeda
January 1993,
International archives of occupational and environmental health,
T Kawai, and
T Yasugi, and
S Horiguchi, and
Y Uchida, and
O Iwami, and
H Iguchi, and
O Inoue, and
T Watanabe, and
H Nakatsuka, and
M Ikeda
August 2019,
Industrial health,
T Kawai, and
T Yasugi, and
S Horiguchi, and
Y Uchida, and
O Iwami, and
H Iguchi, and
O Inoue, and
T Watanabe, and
H Nakatsuka, and
M Ikeda
January 1999,
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals,
T Kawai, and
T Yasugi, and
S Horiguchi, and
Y Uchida, and
O Iwami, and
H Iguchi, and
O Inoue, and
T Watanabe, and
H Nakatsuka, and
M Ikeda
January 1982,
International archives of occupational and environmental health,
T Kawai, and
T Yasugi, and
S Horiguchi, and
Y Uchida, and
O Iwami, and
H Iguchi, and
O Inoue, and
T Watanabe, and
H Nakatsuka, and
M Ikeda
January 2001,
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals,
T Kawai, and
T Yasugi, and
S Horiguchi, and
Y Uchida, and
O Iwami, and
H Iguchi, and
O Inoue, and
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H Nakatsuka, and
M Ikeda
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International archives of occupational and environmental health,
