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Workers with "sensitivity" to toluene diisocyanate (TDI) studied in depth in an attempt to determine mechanisms of bronchial hyperreactivity. Tests included provocative inhalation challenge (PIC) with TDI and methacholine challenge. Blood samples obtained prior to and at various times after PIC were used to measure complement and split products of complement and plasma histamine levels and to determine dose-response slopes of lymphocyte cyclic adenosine monophosphate (cAMP) following stimulation with agonists. TDI-reactive individuals were all reactive to methacholine and responded to PIC with TDI by immediate, delayed, or dual bronchospastic reactions. No change in plasma histamine, total complement levels, or split products of complement were measurable. TDI reactors gave decreased lymphocyte cAMP dose response slopes to stimulation with isoproterenol, prostaglandin E1, and TDI, which suggests that impairment of adrenergic receptors may play an important role in TDI reactivity.
B T Butcher, and
R M Karr, and
C E O'Neil, and
M R Wilson, and
V Dharmarajan, and
J E Salvaggio, and
H Weill
July 1976,
The Journal of allergy and clinical immunology,
B T Butcher, and
R M Karr, and
C E O'Neil, and
M R Wilson, and
V Dharmarajan, and
J E Salvaggio, and
H Weill
January 1967,
American Industrial Hygiene Association journal,
B T Butcher, and
R M Karr, and
C E O'Neil, and
M R Wilson, and
V Dharmarajan, and
J E Salvaggio, and
H Weill
December 1979,
The Journal of allergy and clinical immunology,
B T Butcher, and
R M Karr, and
C E O'Neil, and
M R Wilson, and
V Dharmarajan, and
J E Salvaggio, and
H Weill
June 1989,
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases,
B T Butcher, and
R M Karr, and
C E O'Neil, and
M R Wilson, and
V Dharmarajan, and
J E Salvaggio, and
H Weill
April 1983,
Toxicology and applied pharmacology,
B T Butcher, and
R M Karr, and
C E O'Neil, and
M R Wilson, and
V Dharmarajan, and
J E Salvaggio, and
H Weill
October 1985,
Japanese journal of pharmacology,
B T Butcher, and
R M Karr, and
C E O'Neil, and
M R Wilson, and
V Dharmarajan, and
J E Salvaggio, and
H Weill
October 1982,
The Journal of allergy and clinical immunology,
B T Butcher, and
R M Karr, and
C E O'Neil, and
M R Wilson, and
V Dharmarajan, and
J E Salvaggio, and
H Weill
March 1970,
Archives of environmental health,
B T Butcher, and
R M Karr, and
C E O'Neil, and
M R Wilson, and
V Dharmarajan, and
J E Salvaggio, and
H Weill
January 1964,
American Industrial Hygiene Association journal,
B T Butcher, and
R M Karr, and
C E O'Neil, and
M R Wilson, and
V Dharmarajan, and
J E Salvaggio, and
H Weill
January 1988,
Allergologia et immunopathologia,
