BIOMAT Database Logo BIOMAT Database Logo

The pharmacokinetics of oxytetracycline following intravenous administration in healthy and diseased pigs. 1990

A Pijpers, and E J Schoevers, and H van Gogh, and L A van Leengoed, and I J Visser, and A S van Miert, and J H Verheijden
Department of Herd Health and Reproduction, Faculty of Veterinary Medicine, State University of Utrecht, The Netherlands.

The pharmacokinetics of oxytetracycline (OTC) were studied in healthy pigs and in pigs endobronchially inoculated with Actinobacillus pleuropneumoniae toxins. In two groups of seven pigs OTC was administered intravenously in a single dose of 10 or 50 mg/kg, respectively. OTC was administered to clinically healthy pigs and 7 days later at 3 h after a challenge with A. pleuropneumoniae toxins. Pneumonia developed in toxin-treated pigs. In the challenged pigs there was a decreased distribution-rate constant (alpha) and a significantly increased elimination-rate constant (beta) (P less than 0.05). Moreover, the apparent volume of distribution (Vd beta) was decreased. The elimination half-lives (t1/2 beta) were approximately 6 h in the healthy pigs and 5 h in the diseased animals. There was no difference in the pharmacokinetic profile of OTC following administration of 50 mg/kg compared to 10 mg/kg.

UI MeSH Term Description Entries
D007275 Injections, Intravenous Injections made into a vein for therapeutic or experimental purposes. Intravenous Injections,Injection, Intravenous,Intravenous Injection
D008297 Male Males
D010118 Oxytetracycline A TETRACYCLINE analog isolated from the actinomycete STREPTOMYCES RIMOSUS and used in a wide variety of clinical conditions. Hydroxytetracycline,Bisolvomycin,Geomycin,Oxyterracin,Oxyterracine,Oxytetracid,Oxytetracycline Anhydrous,Oxytetracycline Calcium,Oxytetracycline Dihydrate,Oxytetracycline Hydrochloride,Oxytetracycline Monohydrochloride,Oxytetracycline Sulfate (2:1),Oxytetracycline, (4a beta,5 beta,5a beta,12a beta)-Isomer,Oxytetracycline, (5 beta)-Isomer,Oxytetracycline, Anhydrous,Oxytetracycline, Calcium (1:1) Salt,Oxytetracycline, Disodium Salt, Dihydrate,Oxytetracycline, Sodium Salt,Terramycin
D011014 Pneumonia Infection of the lung often accompanied by inflammation. Experimental Lung Inflammation,Lobar Pneumonia,Lung Inflammation,Pneumonia, Lobar,Pneumonitis,Pulmonary Inflammation,Experimental Lung Inflammations,Inflammation, Experimental Lung,Inflammation, Lung,Inflammation, Pulmonary,Inflammations, Lung,Inflammations, Pulmonary,Lobar Pneumonias,Lung Inflammation, Experimental,Lung Inflammations,Lung Inflammations, Experimental,Pneumonias,Pneumonias, Lobar,Pneumonitides,Pulmonary Inflammations
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D006207 Half-Life The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity. Halflife,Half Life,Half-Lifes,Halflifes
D000189 Actinobacillus Infections Infections with bacteria of the genus ACTINOBACILLUS. Infections, Actinobacillus,Actinobacillus Infection,Infection, Actinobacillus
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013552 Swine Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA). Phacochoerus,Pigs,Suidae,Warthogs,Wart Hogs,Hog, Wart,Hogs, Wart,Wart Hog
D013553 Swine Diseases Diseases of domestic swine and of the wild boar of the genus Sus. Disease, Swine,Diseases, Swine,Swine Disease

Related Publications

A Pijpers, and E J Schoevers, and H van Gogh, and L A van Leengoed, and I J Visser, and A S van Miert, and J H Verheijden
Pharmacokinetics of melamine in pigs following intravenous administration.
March 2008, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
A Pijpers, and E J Schoevers, and H van Gogh, and L A van Leengoed, and I J Visser, and A S van Miert, and J H Verheijden
Pharmacokinetics and renal clearance of oxytetracycline in piglets following intravenous and oral administration.
October 1986, The veterinary quarterly,
A Pijpers, and E J Schoevers, and H van Gogh, and L A van Leengoed, and I J Visser, and A S van Miert, and J H Verheijden
Pharmacokinetics of fenbendazole following intravenous and oral administration to pigs.
May 2000, American journal of veterinary research,
A Pijpers, and E J Schoevers, and H van Gogh, and L A van Leengoed, and I J Visser, and A S van Miert, and J H Verheijden
Pharmacokinetics of pethidine in pigs following intravenous, intramuscular and subcutaneous administration.
December 1998, Journal of veterinary pharmacology and therapeutics,
A Pijpers, and E J Schoevers, and H van Gogh, and L A van Leengoed, and I J Visser, and A S van Miert, and J H Verheijden
Pharmacokinetics of 14 C-ortho-phenylphenol following intravenous administration in pigs.
April 2017, Journal of applied toxicology : JAT,
A Pijpers, and E J Schoevers, and H van Gogh, and L A van Leengoed, and I J Visser, and A S van Miert, and J H Verheijden
Pharmacokinetics of brotizolam in healthy subjects following intravenous and oral administration.
January 1983, British journal of clinical pharmacology,
A Pijpers, and E J Schoevers, and H van Gogh, and L A van Leengoed, and I J Visser, and A S van Miert, and J H Verheijden
Pharmacokinetics of oxiracetam following intravenous and oral administration in healthy volunteers.
January 1984, European journal of drug metabolism and pharmacokinetics,
A Pijpers, and E J Schoevers, and H van Gogh, and L A van Leengoed, and I J Visser, and A S van Miert, and J H Verheijden
Pharmacokinetics of esomeprazole following intravenous and oral administration in healthy dogs.
January 2016, Veterinary medicine (Auckland, N.Z.),
A Pijpers, and E J Schoevers, and H van Gogh, and L A van Leengoed, and I J Visser, and A S van Miert, and J H Verheijden
Oxytetracycline concentrations in healthy and diseased calves.
July 1983, American journal of veterinary research,
A Pijpers, and E J Schoevers, and H van Gogh, and L A van Leengoed, and I J Visser, and A S van Miert, and J H Verheijden
Pharmacokinetics of imipenem-cilastatin following intravenous administration in healthy adult horses.
August 2005, Journal of veterinary pharmacology and therapeutics,
Copied contents to your clipboard!