Biomaterial Database

[Faecal calprotectin in inflammatory bowel disease]. 2011

Taina Sipponen, and Kaija-Leena Kolho

HYKS, Meilahden Sairaala, Gastroenterologian Klinikka.

Calprotectin is a protein released especially from neutrophilic leukocytes and secreted into the intestine during inflammation of the intestinal mucosa. It can be assayed from the feces. Faecal calprotectin has proven to be a useful marker in the diagnostics and monitoring of inflammatory bowel diseases, and application of the assay has been extended from pediatric patients also to adults. Faecal calprotectin is highly elevated in active inflammatory bowel disease, and elevated values in symptomless patients seem to be predictive of exacerbation especially in ulcerative colitis and in Crohn's disease colitis.

UI	MeSH Term	Description	Entries
D007413	Intestinal Mucosa	Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.	Intestinal Epithelium,Intestinal Glands,Epithelium, Intestinal,Gland, Intestinal,Glands, Intestinal,Intestinal Gland,Mucosa, Intestinal
D005243	Feces	Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D015212	Inflammatory Bowel Diseases	Chronic, non-specific inflammation of the GASTROINTESTINAL TRACT. Etiology may be genetic or environmental. This term includes CROHN DISEASE and ULCERATIVE COLITIS.	Bowel Diseases, Inflammatory,Inflammatory Bowel Disease
D015415	Biomarkers	Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, ENVIRONMENTAL EXPOSURE and its effects, disease diagnosis; METABOLIC PROCESSES; SUBSTANCE ABUSE; PREGNANCY; cell line development; EPIDEMIOLOGIC STUDIES; etc.	Biochemical Markers,Biological Markers,Biomarker,Clinical Markers,Immunologic Markers,Laboratory Markers,Markers, Biochemical,Markers, Biological,Markers, Clinical,Markers, Immunologic,Markers, Laboratory,Markers, Serum,Markers, Surrogate,Markers, Viral,Serum Markers,Surrogate Markers,Viral Markers,Biochemical Marker,Biologic Marker,Biologic Markers,Clinical Marker,Immune Marker,Immune Markers,Immunologic Marker,Laboratory Marker,Marker, Biochemical,Marker, Biological,Marker, Clinical,Marker, Immunologic,Marker, Laboratory,Marker, Serum,Marker, Surrogate,Serum Marker,Surrogate End Point,Surrogate End Points,Surrogate Endpoint,Surrogate Endpoints,Surrogate Marker,Viral Marker,Biological Marker,End Point, Surrogate,End Points, Surrogate,Endpoint, Surrogate,Endpoints, Surrogate,Marker, Biologic,Marker, Immune,Marker, Viral,Markers, Biologic,Markers, Immune
D039841	Leukocyte L1 Antigen Complex	A member of the S-100 protein family that is present at high levels in the blood and interstitial fluid in several infectious, inflammatory, and malignant disorders, including rheumatoid arthritis, inflammatory bowel disease, and cystic fibrosis. It is a complex of a light chain (CALGRANULIN A) and a heavy chain (CALGRANULIN B). L1 binds calcium through an EF-hand motif, and has been shown to possess antimicrobial activity.	L1 Antigen,Leukocyte L1 Protein,27E10 Antigen,Calcium-Binding Myeloid Protein P8,14,Calgranulin,Calprotectin,Migratory Inhibitory Factor-Related Protein MRP,Myelomonocytic Antigen L1,Antigen L1, Myelomonocytic,Antigen, 27E10,Antigen, L1,Calcium Binding Myeloid Protein P8,14,L1 Protein, Leukocyte,Migratory Inhibitory Factor Related Protein MRP