Regional brain responses to pleasant and unpleasant IAPS pictures: different networks. 2012

Faten M Aldhafeeri, and Ian Mackenzie, and Tony Kay, and Jamaan Alghamdi, and Vanessa Sluming
School of Health Sciences, The University of Liverpool, UK; Ministry of Health, Radiology Department, Saudi Arabia. F.M.Aldhafeeri@liverpool.ac.uk

OBJECTIVE The purpose of this study was to investigate the brain circuitry involved in the processing of both positive and negative emotions in normal healthy subjects. METHODS we have recruited 15 healthy volunteers (9 males and 6 females, age range 30-60). In this block-design fMRI study, we compared the blood oxygen level dependant (BOLD) signal change as response to pleasant and unpleasant IAPS pictures, each compared to a neutral condition. RESULTS Pleasant pictures versus neutral condition contrast demonstrated significant activation (p(FDRcorrected) <0.05) in bilateral pre-frontal cortex (PFC), anterior and posterior cingulate gyri and temporal lobe. Unpleasant pictures relative to neutral condition exhibit significant activation (p(FDRcorrected) <0.05) in amygdala, hippocampus, parahippocampal gyri, temporal lobe, visual cortex, fusiform gyri, PFC and anterior cingulate gyrus. CONCLUSIONS Amygdala is mainly involved in the processing of negative emotions. Although an overlap in regions involved in the processing of pleasant and unpleasant IAPS pictures exists, the neural network for each is unique.

UI MeSH Term Description Entries
D008279 Magnetic Resonance Imaging Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques. Chemical Shift Imaging,MR Tomography,MRI Scans,MRI, Functional,Magnetic Resonance Image,Magnetic Resonance Imaging, Functional,Magnetization Transfer Contrast Imaging,NMR Imaging,NMR Tomography,Tomography, NMR,Tomography, Proton Spin,fMRI,Functional Magnetic Resonance Imaging,Imaging, Chemical Shift,Proton Spin Tomography,Spin Echo Imaging,Steady-State Free Precession MRI,Tomography, MR,Zeugmatography,Chemical Shift Imagings,Echo Imaging, Spin,Echo Imagings, Spin,Functional MRI,Functional MRIs,Image, Magnetic Resonance,Imaging, Magnetic Resonance,Imaging, NMR,Imaging, Spin Echo,Imagings, Chemical Shift,Imagings, Spin Echo,MRI Scan,MRIs, Functional,Magnetic Resonance Images,Resonance Image, Magnetic,Scan, MRI,Scans, MRI,Shift Imaging, Chemical,Shift Imagings, Chemical,Spin Echo Imagings,Steady State Free Precession MRI
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009415 Nerve Net A meshlike structure composed of interconnecting nerve cells that are separated at the synaptic junction or joined to one another by cytoplasmic processes. In invertebrates, for example, the nerve net allows nerve impulses to spread over a wide area of the net because synapses can pass information in any direction. Neural Networks (Anatomic),Nerve Nets,Net, Nerve,Nets, Nerve,Network, Neural (Anatomic),Networks, Neural (Anatomic),Neural Network (Anatomic)
D010775 Photic Stimulation Investigative technique commonly used during ELECTROENCEPHALOGRAPHY in which a series of bright light flashes or visual patterns are used to elicit brain activity. Stimulation, Photic,Visual Stimulation,Photic Stimulations,Stimulation, Visual,Stimulations, Photic,Stimulations, Visual,Visual Stimulations
D001921 Brain The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM. Encephalon
D004644 Emotions Those affective states which can be experienced and have arousing and motivational properties. Feelings,Regret,Emotion,Feeling,Regrets
D005149 Facial Expression Observable changes of expression in the face in response to emotional stimuli. Face Expression,Expression, Face,Expression, Facial,Face Expressions,Facial Expressions
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

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