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Plasma cortisol profiles were studied by the frequent sampling method in 5 patients with Cushing's disease (CD), 7 patients with Cushing's syndrome due to adrenocortical adenoma (AA), and one patient with bronchogenic carcinoma. Plasma ACTH was measured by radioimmunoassay at 10 min intervals in 2 of the subjects. In CD, there was distinct episodic secretion of cortisol and ACTH; the coefficients of variation about the mean plasma cortisol concentration ranged from 24 to 27%; plasma ACTH ranged from zero to 455 pg/ml with a mean of 94 pg/ml. In AA, the tumour secreted cortisol at a constant rate with little fluctuation; the coefficients of variation of plasma cortisol concentration ranged from 8 to 14%; plasma concentrations of ACTH were always near zero. In the patient with bronchogenic carcinoma, the coefficient of variation of cortisol was 14%. These results were apparent even in profiles of plasma cortisol concentrations measured over only a 6 h period. It is concluded that characteristics of plasma cortisol and ACTH secretory patterns are helpful in differentiating Cushing's syndrome of differing aetiology.
K Yoshida, and
H Satowa, and
A Sato, and
Y Ichikawa, and
J Kream, and
J Levin, and
B Zumoff, and
L Hellman, and
D K Fukushima
August 1977,
The Journal of clinical endocrinology and metabolism,
K Yoshida, and
H Satowa, and
A Sato, and
Y Ichikawa, and
J Kream, and
J Levin, and
B Zumoff, and
L Hellman, and
D K Fukushima
July 2022,
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association,
K Yoshida, and
H Satowa, and
A Sato, and
Y Ichikawa, and
J Kream, and
J Levin, and
B Zumoff, and
L Hellman, and
D K Fukushima
January 1977,
Clinical endocrinology,
K Yoshida, and
H Satowa, and
A Sato, and
Y Ichikawa, and
J Kream, and
J Levin, and
B Zumoff, and
L Hellman, and
D K Fukushima
March 1968,
Annals of internal medicine,
K Yoshida, and
H Satowa, and
A Sato, and
Y Ichikawa, and
J Kream, and
J Levin, and
B Zumoff, and
L Hellman, and
D K Fukushima
January 2012,
Nederlands tijdschrift voor geneeskunde,
K Yoshida, and
H Satowa, and
A Sato, and
Y Ichikawa, and
J Kream, and
J Levin, and
B Zumoff, and
L Hellman, and
D K Fukushima
May 1971,
The Journal of clinical endocrinology and metabolism,
K Yoshida, and
H Satowa, and
A Sato, and
Y Ichikawa, and
J Kream, and
J Levin, and
B Zumoff, and
L Hellman, and
D K Fukushima
August 1978,
Acta endocrinologica,
K Yoshida, and
H Satowa, and
A Sato, and
Y Ichikawa, and
J Kream, and
J Levin, and
B Zumoff, and
L Hellman, and
D K Fukushima
February 1991,
IEEE transactions on bio-medical engineering,
K Yoshida, and
H Satowa, and
A Sato, and
Y Ichikawa, and
J Kream, and
J Levin, and
B Zumoff, and
L Hellman, and
D K Fukushima
February 2006,
BMJ (Clinical research ed.),
K Yoshida, and
H Satowa, and
A Sato, and
Y Ichikawa, and
J Kream, and
J Levin, and
B Zumoff, and
L Hellman, and
D K Fukushima
January 1970,
Problemy endokrinologii,
