-transparent.png){kind=logo}
Unusually large, oval and pleomorphic secretory granules were noted by electron microscopy in an acidophilic adenoma of the pituitary. The tumor, which was removed by surgery from a 42-year-old woman with elevated blood growth hormone levels and the clinical features of acromegaly, was found to contain growth hormone by the immunoperoxidase technique. This ultrastructural abnormality of secretory granules was not reported so far and was not seen among the 58 cases of growth hormone-producing adenomas investigated in our laboratory. The present case clearly shows that the cytogenesis and cellular composition of pituitary adenomas cannot be determined by solely examining the size and shape of secretory granules.
K Kovacs, and
E Horvath, and
D W Killinger, and
M Platts, and
H S Smyth
May 2005,
Journal of neuro-oncology,
K Kovacs, and
E Horvath, and
D W Killinger, and
M Platts, and
H S Smyth
January 1985,
Zentralblatt fur Neurochirurgie,
K Kovacs, and
E Horvath, and
D W Killinger, and
M Platts, and
H S Smyth
March 1986,
[Hokkaido igaku zasshi] The Hokkaido journal of medical science,
K Kovacs, and
E Horvath, and
D W Killinger, and
M Platts, and
H S Smyth
January 2006,
Neuro endocrinology letters,
K Kovacs, and
E Horvath, and
D W Killinger, and
M Platts, and
H S Smyth
July 1988,
Histology and histopathology,
K Kovacs, and
E Horvath, and
D W Killinger, and
M Platts, and
H S Smyth
January 1985,
Cancer,
K Kovacs, and
E Horvath, and
D W Killinger, and
M Platts, and
H S Smyth
November 2012,
Neurocirugia (Asturias, Spain),
K Kovacs, and
E Horvath, and
D W Killinger, and
M Platts, and
H S Smyth
January 2013,
World neurosurgery,
K Kovacs, and
E Horvath, and
D W Killinger, and
M Platts, and
H S Smyth
January 1995,
British journal of neurosurgery,
K Kovacs, and
E Horvath, and
D W Killinger, and
M Platts, and
H S Smyth
January 1995,
British journal of neurosurgery,
