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Authors examined the effect of D-penicillamin (Pw) on liver cirrhosis induced by chronic CCl4 and phenobarbital (Pb) treatment in Fischer 344 rats. Morphometric analysis of quantity of connective tissue fibres did not show decrease on the effect of Pe treatment. Quantity of hydroxiproline, which is one of the parameters of coll ahen decrease, did not change significantly on effect of drug, but only compared to CCl4 and Pb treated control. Quantity of glycosaminoglycan showed increase following Pe treatment. Lymphocyte stimulation by Con-A was different in CCl4 and Pb and Pe treated groups, respectively. According to our examinations in case of liver fibrosis cirrhosis induced by CCL4-PB treatment in rats the Pe treatment proved to be unsuccessful. It seems that Pe is effective only in forms of cirrhosis accompanied by significant copper accumulation, by decrease of toxic effects of copper.
Z Schaff, and
K Lapis, and
B Szende, and
A Jeney, and
R Gonzales Cabello, and
P Gergely, and
K Simon, and
A Divald, and
F Timár, and
J Major
January 1983,
Patologicheskaia fiziologiia i eksperimental'naia terapiia,
Z Schaff, and
K Lapis, and
B Szende, and
A Jeney, and
R Gonzales Cabello, and
P Gergely, and
K Simon, and
A Divald, and
F Timár, and
J Major
January 1979,
Patologicheskaia fiziologiia i eksperimental'naia terapiia,
Z Schaff, and
K Lapis, and
B Szende, and
A Jeney, and
R Gonzales Cabello, and
P Gergely, and
K Simon, and
A Divald, and
F Timár, and
J Major
March 1981,
Biulleten' eksperimental'noi biologii i meditsiny,
Z Schaff, and
K Lapis, and
B Szende, and
A Jeney, and
R Gonzales Cabello, and
P Gergely, and
K Simon, and
A Divald, and
F Timár, and
J Major
December 2020,
Annals of medicine and surgery (2012),
Z Schaff, and
K Lapis, and
B Szende, and
A Jeney, and
R Gonzales Cabello, and
P Gergely, and
K Simon, and
A Divald, and
F Timár, and
J Major
January 1989,
Fundamental & clinical pharmacology,
Z Schaff, and
K Lapis, and
B Szende, and
A Jeney, and
R Gonzales Cabello, and
P Gergely, and
K Simon, and
A Divald, and
F Timár, and
J Major
March 1980,
Problemy tuberkuleza,
Z Schaff, and
K Lapis, and
B Szende, and
A Jeney, and
R Gonzales Cabello, and
P Gergely, and
K Simon, and
A Divald, and
F Timár, and
J Major
January 1990,
Patologia polska,
Z Schaff, and
K Lapis, and
B Szende, and
A Jeney, and
R Gonzales Cabello, and
P Gergely, and
K Simon, and
A Divald, and
F Timár, and
J Major
October 1981,
Research communications in chemical pathology and pharmacology,
Z Schaff, and
K Lapis, and
B Szende, and
A Jeney, and
R Gonzales Cabello, and
P Gergely, and
K Simon, and
A Divald, and
F Timár, and
J Major
May 1996,
Biochemical Society transactions,
Z Schaff, and
K Lapis, and
B Szende, and
A Jeney, and
R Gonzales Cabello, and
P Gergely, and
K Simon, and
A Divald, and
F Timár, and
J Major
February 1988,
Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue europeenne pour les sciences medicales et pharmacologiques,
