Mineral trioxide aggregate and Portland cement promote biomineralization in vivo. 2012

Luonothar Antunes Schmitt Dreger, and Wilson Tadeu Felippe, and Jessie Fabiola Reyes-Carmona, and Gabriela Santos Felippe, and Eduardo Antunes Bortoluzzi, and Mara Cristina Santos Felippe
Postgraduate Program, School of Dentistry, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.

BACKGROUND Mineral trioxide aggregate (MTA) and Portland cement have been shown to be bioactive because of their ability to produce biologically compatible carbonated apatite. This study analyzed the interaction of MTA and white Portland cement with dentin in vivo. METHODS Seventy-two human dentin tubes were filled with MTA Branco, MTA BIO, and white Portland cement + 20% bismuth oxide (PC1) or PC1 + 10% of calcium chloride (PC2) and implanted subcutaneously in 18 rats at 4 sites from the dorsal area. Empty dentin tubes, implanted in rats of a pilot study, were used as control. After 30, 60, and 90 days, the animals were killed, and the dentin tubes were retrieved for scanning electron microscope analysis. RESULTS In the periods of 30 and 60 days, the mineral deposition in the material-dentin interface (interfacial layer) and in the interior of dentinal tubules was detected in more tubes filled with MTA Branco and MTA BIO than in tubes filled with PC1 and PC2. After 90 days, the interfacial layer and intratubular mineralization were detected in all tubes except for 3 and 1 of the tubes filled with PC2, respectively. CONCLUSIONS It was concluded that all the cements tested were bioactive. The cements released some of their components in the tissue capable of stimulating mineral deposition in the cement-dentin interface and in the interior of the dentinal tubules. MTA BIO and MTA Branco were more effective in promoting the biomineralization process than Portland cements, mainly after 30 and 60 days.

UI MeSH Term Description Entries
D008297 Male Males
D008855 Microscopy, Electron, Scanning Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY. Scanning Electron Microscopy,Electron Scanning Microscopy,Electron Microscopies, Scanning,Electron Microscopy, Scanning,Electron Scanning Microscopies,Microscopies, Electron Scanning,Microscopies, Scanning Electron,Microscopy, Electron Scanning,Microscopy, Scanning Electron,Scanning Electron Microscopies,Scanning Microscopies, Electron,Scanning Microscopy, Electron
D010087 Oxides Binary compounds of oxygen containing the anion O(2-). The anion combines with metals to form alkaline oxides and non-metals to form acidic oxides. Oxide
D010758 Phosphorus A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions. Black Phosphorus,Phosphorus-31,Red Phosphorus,White Phosphorus,Yellow Phosphorus,Phosphorus 31,Phosphorus, Black,Phosphorus, Red,Phosphorus, White,Phosphorus, Yellow
D010865 Pilot Projects Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work. Pilot Studies,Pilot Study,Pilot Project,Project, Pilot,Projects, Pilot,Studies, Pilot,Study, Pilot
D001729 Bismuth A metallic element that has the atomic symbol Bi, and atomic number 83. Its principal isotope is Bismuth 209.
D002113 Calcification, Physiologic Process by which organic tissue becomes hardened by the physiologic deposit of calcium salts. Bone Mineralization,Calcification, Physiological,Physiologic Calcification,Mineralization, Bone,Physiological Calcification
D002118 Calcium A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. Coagulation Factor IV,Factor IV,Blood Coagulation Factor IV,Calcium-40,Calcium 40,Factor IV, Coagulation
D002122 Calcium Chloride A salt used to replenish calcium levels, as an acid-producing diuretic, and as an antidote for magnesium poisoning. Calcium Chloride Dihydrate,Calcium Chloride, Anhydrous
D003738 Dental Cements Substances used to bond COMPOSITE RESINS to DENTAL ENAMEL and DENTIN. These bonding or luting agents are used in restorative dentistry, ROOT CANAL THERAPY; PROSTHODONTICS; and ORTHODONTICS. Dental Adhesives,Luting Agents,Orthodontic Adhesives,Cement, Dental,Cements, Dental,Dental Cement,Adhesive, Dental,Adhesive, Orthodontic,Adhesives, Dental,Adhesives, Orthodontic,Dental Adhesive,Luting Agent,Orthodontic Adhesive

Related Publications

Luonothar Antunes Schmitt Dreger, and Wilson Tadeu Felippe, and Jessie Fabiola Reyes-Carmona, and Gabriela Santos Felippe, and Eduardo Antunes Bortoluzzi, and Mara Cristina Santos Felippe
April 2003, Australian endodontic journal : the journal of the Australian Society of Endodontology Inc,
Luonothar Antunes Schmitt Dreger, and Wilson Tadeu Felippe, and Jessie Fabiola Reyes-Carmona, and Gabriela Santos Felippe, and Eduardo Antunes Bortoluzzi, and Mara Cristina Santos Felippe
February 2010, Journal of endodontics,
Luonothar Antunes Schmitt Dreger, and Wilson Tadeu Felippe, and Jessie Fabiola Reyes-Carmona, and Gabriela Santos Felippe, and Eduardo Antunes Bortoluzzi, and Mara Cristina Santos Felippe
July 2010, Journal of endodontics,
Luonothar Antunes Schmitt Dreger, and Wilson Tadeu Felippe, and Jessie Fabiola Reyes-Carmona, and Gabriela Santos Felippe, and Eduardo Antunes Bortoluzzi, and Mara Cristina Santos Felippe
January 2008, Journal of applied oral science : revista FOB,
Luonothar Antunes Schmitt Dreger, and Wilson Tadeu Felippe, and Jessie Fabiola Reyes-Carmona, and Gabriela Santos Felippe, and Eduardo Antunes Bortoluzzi, and Mara Cristina Santos Felippe
April 2003, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics,
Luonothar Antunes Schmitt Dreger, and Wilson Tadeu Felippe, and Jessie Fabiola Reyes-Carmona, and Gabriela Santos Felippe, and Eduardo Antunes Bortoluzzi, and Mara Cristina Santos Felippe
March 2006, International endodontic journal,
Luonothar Antunes Schmitt Dreger, and Wilson Tadeu Felippe, and Jessie Fabiola Reyes-Carmona, and Gabriela Santos Felippe, and Eduardo Antunes Bortoluzzi, and Mara Cristina Santos Felippe
May 2009, Journal of endodontics,
Luonothar Antunes Schmitt Dreger, and Wilson Tadeu Felippe, and Jessie Fabiola Reyes-Carmona, and Gabriela Santos Felippe, and Eduardo Antunes Bortoluzzi, and Mara Cristina Santos Felippe
January 2008, Journal of endodontics,
Luonothar Antunes Schmitt Dreger, and Wilson Tadeu Felippe, and Jessie Fabiola Reyes-Carmona, and Gabriela Santos Felippe, and Eduardo Antunes Bortoluzzi, and Mara Cristina Santos Felippe
June 2009, European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry,
Luonothar Antunes Schmitt Dreger, and Wilson Tadeu Felippe, and Jessie Fabiola Reyes-Carmona, and Gabriela Santos Felippe, and Eduardo Antunes Bortoluzzi, and Mara Cristina Santos Felippe
October 2006, Journal of applied oral science : revista FOB,
Copied contents to your clipboard!