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Twenty-six women with invasive cervical cancer were examined for lymphocyte responsiveness to phytohemagglutinin (PHA) herpes simplex virus (HSV). Blood specimens were obtained from each patient before radiation therapy and separated into subpopulations by Ficoll-Hypaque centrifugation. Lymphocytes were cultured in RPMI-1640 containing autologous plasma and exposed to PHA, HSV-1, HSV-2, and control antigens. The results compared with those of women having negative Papanicolaou smears and matched to the cancer patients by age, race, and socioeconomic class revealed significant differences in blastogenic response (3H-thymidine) to HSV-2 antigens. Results from groups with known HSV-1 and HSV-2 infections indicated that differences were associated with the cancer patients having a higher frequency of HSV-2 infection. Results generally agreed with the findings of previous studies in which serologic test procedures were used.
J W Smith, and
J E Torres, and
N D Holmquist
January 1977,
Cytobios,
J W Smith, and
J E Torres, and
N D Holmquist
December 1999,
La Revue du praticien,
J W Smith, and
J E Torres, and
N D Holmquist
May 1988,
Clinical and experimental immunology,
J W Smith, and
J E Torres, and
N D Holmquist
January 1976,
Virologie,
J W Smith, and
J E Torres, and
N D Holmquist
November 2006,
Cancer gene therapy,
J W Smith, and
J E Torres, and
N D Holmquist
October 1980,
Journal of the Medical Association of Thailand = Chotmaihet thangphaet,
J W Smith, and
J E Torres, and
N D Holmquist
October 2002,
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
J W Smith, and
J E Torres, and
N D Holmquist
October 1984,
Liver,
J W Smith, and
J E Torres, and
N D Holmquist
June 1999,
Deutsche medizinische Wochenschrift (1946),
J W Smith, and
J E Torres, and
N D Holmquist
February 1974,
Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association,
