Biomaterial Database

Pik1-ing clathrin adaptors. 2012

Yidi Sun, and David G Drubin

Department of Molecular and Cell Biology, University of California Berkeley, California 94720-3202, USA.

Clathrin adaptor proteins are essential for clathrin-coated vesicle biogenesis, yet the mechanisms governing their recruitment and interactions remain incompletely defined. The clathrin adaptors Gga and AP-1 are now shown to be recruited sequentially to the trans-Golgi network in two waves of clathrin coat assembly, coupled by Pik1-mediated phosphatidylinositol-4-phosphate synthesis. These findings reveal mechanistic insights into the functional and regulatory relationships between these clathrin adaptors.

UI	MeSH Term	Description	Entries
D018129	Phosphatidylinositol Phosphates	Phosphatidylinositols in which one or more alcohol group of the inositol has been substituted with a phosphate group.	Polyphosphoinositides,Phosphatidyl Inositol Phosphates,Polyphosphoinositide,Inositol Phosphates, Phosphatidyl,Phosphates, Phosphatidyl Inositol,Phosphates, Phosphatidylinositol
D019870	1-Phosphatidylinositol 4-Kinase	An enzyme that catalyzes the conversion of phosphatidylinositol (PHOSPHATIDYLINOSITOLS) to phosphatidylinositol 4-phosphate, the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate.	Phosphatidylinositol 4-Kinase,PtdIns 4-Kinase,PI 4-Kinase,Phosphatidylinositiol Kinase,Phosphatidylinositol Kinase Type II,Phosphoinositide Kinase,1 Phosphatidylinositol 4 Kinase,Kinase, Phosphatidylinositiol,Kinase, Phosphoinositide,PI 4 Kinase,Phosphatidylinositol 4 Kinase,PtdIns 4 Kinase
D021601	trans-Golgi Network	A network of membrane compartments, located at the cytoplasmic side of the GOLGI APPARATUS, where proteins and lipids are sorted for transport to various locations in the cell or cell membrane.	trans-Golgi Region,Network, trans-Golgi,Region, trans-Golgi,Regions, trans-Golgi,trans Golgi Network,trans Golgi Region,trans-Golgi Regions
D029701	Saccharomyces cerevisiae Proteins	Proteins obtained from the species SACCHAROMYCES CEREVISIAE. The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes.	Baker's Yeast Proteins,S cerevisiae Proteins
D033942	Adaptor Proteins, Vesicular Transport	A class of proteins involved in the transport of molecules via TRANSPORT VESICLES. They perform functions such as binding to the cell membrane, capturing cargo molecules and promoting the assembly of CLATHRIN. The majority of adaptor proteins exist as multi-subunit complexes, however monomeric varieties have also been found.	Clathrin Adaptor,Clathrin Adaptor Protein Complex,Clathrin Assembly Protein,Clathrin Assembly Protein Complex,Clathrin Assembly Proteins,Clathrin-Associated Adaptor,Clathrin-Associated Protein,Vesicular Transport Adaptor Protein,Vesicular Transport Adaptor Protein Complex,Vesicular Transport Adaptor Proteins,Adaptor Protein Complexes, Vesicular Transport,Clathrin Adaptor Protein Complexes,Clathrin Adaptors,Clathrin Assembly Protein Complexes,Clathrin-Associated Adaptors,Clathrin-Associated Proteins,Vesicular Transport Adaptor Protein Complexes,Adaptor, Clathrin,Adaptor, Clathrin-Associated,Adaptors, Clathrin,Adaptors, Clathrin-Associated,Assembly Protein, Clathrin,Assembly Proteins, Clathrin,Clathrin Associated Adaptor,Clathrin Associated Adaptors,Clathrin Associated Protein,Clathrin Associated Proteins,Protein, Clathrin Assembly,Protein, Clathrin-Associated