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Epstein-Barr Virus (EBV)-Associated Haemophagocytic Syndrome. 2012
Lorenza Torti, and
Luigi M Larocca, and
Giuseppina Massini, and
Annarosa Cuccaro, and
Elena Maiolo, and
Rosaria Santangelo, and
Maria Bianchi, and
Mariano Alberto Pennisi, and
Stefan Hohaus, and
Luciana Teofili
Department of Hematology, Catholic University, Rome, Italy.
We describe the case of a 17- year old female who developed fatal haemophagocytic syndrome (HPS) one month following acute infection caused by Epstein-Barr virus (EBV). Despite initiation of treatment and reduction of EBV load, laboratory signs of HPS as severe cytopenia, hypofibrinogenemia, hyperferritinemia and hypertriglyceridemia persisted, and the patient died of multiorgan failure. HPS is a rare, but life-threatening complication of EBV infection.
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