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In order to investigate the relationship between mutation and carcinogenesis in vivo, a method has been developed in which somatic mutation can be studied in specific organs of Chinese hamsters after acute dosing with chemical carcinogens. In preliminary experiments an increase in mutation was detected in cultures derived from lung tissue of hamsters after intraperitoneal dosing with the direct-acting mutagen and weak carcinogen, ethyl methanesulphonate, or with diethylnitrosamine, a carcinogen which requires metabolic activation before mutagenic activity can be demonstrated in vitro. Subsequent experiments have shown the induction of mutation in cells dereived from the bladder of animals dosed with diethylnitrosamine or methyl nitrosourea and in a variety of tissues from animals dosed with methane-sulphonates, 2-acetylaminofluorene and 3-methylcholanthrene.
B J Dean, and
G Hodson-Walker, and
K R Senner
November 1992,
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B J Dean, and
G Hodson-Walker, and
K R Senner
September 1982,
Cancer research,
B J Dean, and
G Hodson-Walker, and
K R Senner
April 1974,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
B J Dean, and
G Hodson-Walker, and
K R Senner
January 1983,
Basic life sciences,
B J Dean, and
G Hodson-Walker, and
K R Senner
November 1999,
Carcinogenesis,
B J Dean, and
G Hodson-Walker, and
K R Senner
November 1976,
Nature,
B J Dean, and
G Hodson-Walker, and
K R Senner
May 1974,
Proceedings of the National Academy of Sciences of the United States of America,
B J Dean, and
G Hodson-Walker, and
K R Senner
August 1988,
Cancer research,
B J Dean, and
G Hodson-Walker, and
K R Senner
January 1978,
Journal of environmental pathology and toxicology,
B J Dean, and
G Hodson-Walker, and
K R Senner
January 1993,
Voprosy onkologii,
