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Regulatory region of three bithorax complex genes, Ultrabithorax (Ubx), abdominal-A (abd-A), and Abdominal-B (Abd-B) can be divided into nine iab domains, capable of directing expression of one of the genes in certain abdominal parasegment of Drosophila. In the Abd-B regulatory region, three insulators were identified, including Fab-7 and Fab-8, which flanked the iab-7domain, and Mcp, which separated the Abd-B and abd-A regulatory regions. It was suggested that boundary insulators formed a barrier between active and repressed chromatin. In the present study, using the yellow and white reporter genes and different combinations of known insulators, Mcp, Fab-7, and Fab-8, it was demonstrated that only specific interaction of two insulators was capable of isolation of active and repressed chromatin, i.e., the formation of independent expression domains.
O V Kyrchanova, and
T A Ivleva, and
P G Georgiev
December 1986,
Developmental biology,
O V Kyrchanova, and
T A Ivleva, and
P G Georgiev
January 2020,
The International journal of developmental biology,
O V Kyrchanova, and
T A Ivleva, and
P G Georgiev
July 1983,
Science (New York, N.Y.),
O V Kyrchanova, and
T A Ivleva, and
P G Georgiev
November 2002,
Development (Cambridge, England),
O V Kyrchanova, and
T A Ivleva, and
P G Georgiev
January 1998,
Biochemistry and cell biology = Biochimie et biologie cellulaire,
O V Kyrchanova, and
T A Ivleva, and
P G Georgiev
December 1987,
Molecular & general genetics : MGG,
O V Kyrchanova, and
T A Ivleva, and
P G Georgiev
October 1994,
Genetics,
O V Kyrchanova, and
T A Ivleva, and
P G Georgiev
November 2005,
Genetika,
O V Kyrchanova, and
T A Ivleva, and
P G Georgiev
November 1999,
Genetics,
O V Kyrchanova, and
T A Ivleva, and
P G Georgiev
November 2020,
Genetics,
